Effect of Metformin on Oral Implant Healing in Type 2 Diabetic Rats

Hdl Handle:
http://hdl.handle.net/10675.2/317692
Title:
Effect of Metformin on Oral Implant Healing in Type 2 Diabetic Rats
Authors:
Inouye, Kimberly Ann
Abstract:
In dentistry today, endosseous implants have become a generally favorable treatment option for edentulous spaces in the oral cavity because of proven biocompatibility, potential for esthetics, and good long term prognosis.(1) However, there are risk factors to consider that may affect and impair the osseointegration of an implant. A possible risk factor is type 2 diabetes mellitus (T2DM), a metabolic disorder characterized by insulin resistance at the target tissue site and progressive destruction of the pancreatic beta cells that ultimately results in prolonged periods of hyperglycemia.(2) When the serum glucose levels were persistently high, it was shown to impair bone metabolism and thus, has the potential to impair implant osseointegration.(3)
Affiliation:
Department of Oral Biology
Issue Date:
Apr-2011
URI:
http://hdl.handle.net/10675.2/317692
Type:
Thesis
Language:
en
Description:
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Appears in Collections:
Theses and Dissertations; Department of Oral Biology Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorInouye, Kimberly Annen
dc.date.accessioned2014-06-02T21:39:54Z-
dc.date.available2014-06-02T21:39:54Z-
dc.date.issued2011-04-
dc.identifier.urihttp://hdl.handle.net/10675.2/317692-
dc.descriptionThe file you are attempting to access is currently restricted to Augusta University. Please log in with your NetID if off campus.en
dc.description.abstractIn dentistry today, endosseous implants have become a generally favorable treatment option for edentulous spaces in the oral cavity because of proven biocompatibility, potential for esthetics, and good long term prognosis.(1) However, there are risk factors to consider that may affect and impair the osseointegration of an implant. A possible risk factor is type 2 diabetes mellitus (T2DM), a metabolic disorder characterized by insulin resistance at the target tissue site and progressive destruction of the pancreatic beta cells that ultimately results in prolonged periods of hyperglycemia.(2) When the serum glucose levels were persistently high, it was shown to impair bone metabolism and thus, has the potential to impair implant osseointegration.(3)en
dc.language.isoenen
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.-
dc.subjectGlucoseen
dc.subjectDiabetesen
dc.subjectDentistryen
dc.subjectOral Implanten
dc.subjectMetforminen
dc.titleEffect of Metformin on Oral Implant Healing in Type 2 Diabetic Ratsen
dc.typeThesisen
dc.contributor.departmentDepartment of Oral Biologyen
dc.description.advisorBorke, Jamesen
dc.description.committeeHerold, Robert; Mozaffari, Mahmood; Elsalanty, Mohammeden
dc.description.degreeMaster of Science (M.S.)-
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