Molecular and Biochemical Characterization and Regulation of Folate Transport Proteins in Retinal Muller Cells

Hdl Handle:
http://hdl.handle.net/10675.2/317543
Title:
Molecular and Biochemical Characterization and Regulation of Folate Transport Proteins in Retinal Muller Cells
Authors:
Bozard, B. Renee
Abstract:
Of the special sensory systems of vision, audition, olfaction, and tactile, the sense of vision is by far the most utilized (by sighted persons) in providing information about our surroundings. The visual pathway involves the retina as well as the brain and maintenance of retinal function is paramount for normal vision. Among the cells required to maintain the retina are Müller cells. This project was undertaken to examine the process by which retinal Müller cells acquire the essential vitamin folate. To lay the foundation of this work, this introductory chapter will describe (1) the retina, the tissue being studied, (2) the retinal Müller cell, the specific cell type examined, (3) folate and the known mechanisms of folate uptake described for other cells, (4) diseases associated with folate deficiency, (5) mechanisms of folate uptake in retina, and (6) factors that may regulate folate uptake in retinal Müller cells.
Affiliation:
Department of Cellular Biology and Anatomy
Issue Date:
Jul-2011
URI:
http://hdl.handle.net/10675.2/317543
Additional Links:
http://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/889027355?accountid=12365
Type:
Dissertation
Language:
en_US
Appears in Collections:
Department of Cellular Biology and Anatomy Theses and Dissertations; Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorBozard, B. Reneeen
dc.date.accessioned2014-05-27T23:40:22Z-
dc.date.available2014-05-27T23:40:22Z-
dc.date.issued2011-07-
dc.identifier.urihttp://hdl.handle.net/10675.2/317543-
dc.description.abstractOf the special sensory systems of vision, audition, olfaction, and tactile, the sense of vision is by far the most utilized (by sighted persons) in providing information about our surroundings. The visual pathway involves the retina as well as the brain and maintenance of retinal function is paramount for normal vision. Among the cells required to maintain the retina are Müller cells. This project was undertaken to examine the process by which retinal Müller cells acquire the essential vitamin folate. To lay the foundation of this work, this introductory chapter will describe (1) the retina, the tissue being studied, (2) the retinal Müller cell, the specific cell type examined, (3) folate and the known mechanisms of folate uptake described for other cells, (4) diseases associated with folate deficiency, (5) mechanisms of folate uptake in retina, and (6) factors that may regulate folate uptake in retinal Müller cells.en
dc.language.isoen_USen
dc.relation.urlhttp://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/889027355?accountid=12365en
dc.rightsAccess restricted to authorized Georgia Regents University users only.en
dc.subjectRetinaen
dc.subjectRetinal glial cellsen
dc.subjectFolate Transporten
dc.subjectMuller Cellsen
dc.titleMolecular and Biochemical Characterization and Regulation of Folate Transport Proteins in Retinal Muller Cellsen
dc.typeDissertationen
dc.contributor.departmentDepartment of Cellular Biology and Anatomyen
dc.contributor.corporatenameGeorgia Regents Universityen
dc.description.advisorSmith, Sylviaen
dc.description.committeeGanapathy, Vadivel; Prasad, Putter; Martin, Pamela; Hamrick, Marken
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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