Welcome to Scholarly Commons, the institutional repository for Augusta University.

 

 

The University Libraries offer advisory support to faculty who want to create open access journal publications or have questions regarding copyright, author rights, and publisher contracts.  Individuals may submit scholarly works or departments may submit a collection of works. Additional information about Scholarly Commons can be found on this Research Guide.

  • Socio-Economic Factors and Cardiovascular Disease Mortality: A County-Level Analysis of Georgia

    Adepu, Sanjana (Augusta University, 2019-10)
    Background: With over 20,000 deaths (~1 in every 3 deaths) per year, Cardiovascular Disease (CVD) is the leading cause of death in Georgia. Studying the overall impact of multiple socioeconomic factors (SES) on CVD could lead to a better understanding of the determinants of public health. The factors examined in this study include physical inactivity, median household income, health insurance, and air quality. While several studies examine the effects of a single SES factor on CVD, this study analyses multiple SES factors on CVD death rates in Georgia. Methods: County-level socioeconomic factors for Georgia were obtained from The Center for Disease Control and Prevention. A multiple regression model was developed to identify the factors that explain CVD death rates in Georgia. Results: In Georgia, the median household income and annual average ambient concentrations of PM2.5 were the most significant factors. Lower levels of median household income were associated with higher CVD death rates; higher concentrations of PM2.5 were associated with higher CVD death rates. Additionally, leisure-time physical inactivity was marginally significant, which indicates higher percentages of physical inactivity led to higher CVD death rates. Conclusion: Policies that increase median household income and lower annual ambient concentrations may also have secondary benefits to public health and, in particular, cardiovascular disease death rates in Georgia. Future studies could expand upon this analysis by studying the effects of SES on the national level.
  • MYCN STIMULATES GLYCINE DECARBOXYLASE (GLDC) IN NEUROBLASTOMA TO PROMOTE TUMORIGENESIS

    Alptekin, Ahmet; Biomedical Sciences (Augusta University, 2019-05)
    Genomic amplification of the oncogene MYCN is a major driver in the development of high-risk neuroblastoma, a pediatric cancer with poor prognosis. Given the challenge in targeting MYCN directly for therapy, we sought to identify MYCN-dependent metabolic vulnerabilities that can be targeted therapeutically. Here, we report that the gene encoding glycine decarboxylase (GLDC), which catalyzes the first and rate-limiting step in glycine breakdown with the production of one-carbon unit 5,10-methylene-tetrahydrofolate, is a direct transcriptional target of MYCN. GLDC expression is markedly elevated in MYCN-amplified neuroblastoma tumors and cell lines. This transcriptional upregulation of GLDC expression is of functional significance, as GLDC depletion by RNA interference inhibits the proliferation and tumorigenicity of MYCN-amplified neuroblastoma cell lines. Metabolomic profiling reveals that GLDC knockdown disrupts purine and central carbon metabolism and reduces citrate production, leading to a decrease in the steady-state levels of cholesterol and fatty acids, which are essential to sustain cell proliferation. In addition, microarray gene expression profiling shows that GLDC silencing downregulates genes involved in regulation of cell proliferation. These findings suggest that GLDC is a key player in MYCN-regulated cancer metabolism and a potential drug target in the treatment of high-risk neuroblastoma.
  • The Antidote: Volume 1

    Wang, Bing; Allen, Griffen; Cardoso, Leticia; Chandra, Upasana; Stephens, Michael; Iyoha, Ehiremen; Juarez, Erick; McKenzie, Savannah; Owen, Jack; Jalla, Rasmita; et al. (Augusta University Libraries, 2019)
  • Terminal competencies of the baccalaureate nursing graduate

    Eberhart, Aeris Dee; School of Nursing (1974-05)

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