Scholarly Commons @Augusta University


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AU COVID-19 Research and Scholarship [99]
AU Open Access Pilot Program Awards [8]
AU Syllabi Repository [1]
AU Teaching Commons [6]
Wellstar MCG Health (formerly AU Health) [4]
University Publications [39]
Special Collections and Archives [2339]
  • Faculty Senate Newsletter: The Tea with Dr. T (April 2024)

    Curry-McCoy, Tiana (Augusta University, 2024-04)
  • Blinding Crystals: Monosodium Urate Crystals and Diabetic Retinopathy

    Amanamba, Udochukwu; Augusta State University Honors Thesis; Augusta State University Honors Thesis (Augusta University, 2021)
    Diabetic retinopathy (DR) is a common complication of diabetes and the main cause of blindness among adults of working age. Previous studies have established that high blood glucose levels (hyperglycemia) promote chronic sub-clinical inflammation which in turn causes retinal tissue injury and development of DR. It has also been shown that increased levels of uric acid, a by-product of the purine metabolism, generates crystals of monosodium urate (MSU) which could contribute to retinal inflammation and to the development of DR. My honors thesis project focused on investigating the molecular basis of inflammation in diabetic retinopathy (DR), specifically how MSU stimulates sterile inflammation in retinal blood vessels cells and in other retinal cells through the induction of the NLRP3-inflammasome. Human retinal endothelial (HuREC) and Human retinal epithelial cells (HuRPE) were treated with clinically relevant doses of MSU (6mg/dL) or high glucose (HG 25mM) or a combination of both. The expression of NLRP3 inflammasome constituents such as IL-1, NLRP3 protein, Toll-like receptor (TLR4), Gasdermin D (GSDMD) and Thioredoxin-interacting protein (TXNIP) were monitored using Western blotting analysis and ELISA assay. Morphometric analysis and ANOVA statistical approaches were employed to analyze the data. The results obtained showed that HuREC are more responsive to MSU alone than HuRPE. However, in all conditions, MSU significantly potentiated the production of inflammatory constituents of the NLRP3 inflammasome. Overall, the results of my studies support MSU as a contributing factor to the pathogenesis of DR. This suggests that uricemia should be monitored in diabetic patients and hypouricemic drugs could be helpful in combating DR and vision loss in diabetic patients.
  • Attitudes About Differential Treatment of Crack and Cocaine in Terms of Legality

    Pollard, Elinita M.; Augusta State University Honors Thesis; Augusta State University Honors Thesis (Augusta University, 2021)
    Attitudes concerning addiction influence how an individual feels about a plethora of issues related to substance abuse. Broadus and Evans (2015) developed an instrument to measure an individual’s attitude toward addiction called the Public Attitudes About Addictions Survey (PAAAS). Their research suggested that an individual’s perception of drug addiction aligns with one of the following models of addiction: the psychological model, sociological model, disease model, nature model, or moral model. Broadus and Evans argue one’s attitude may influence how an individual feels about receiving addiction counseling, drug-related judicial decisions, and formation of drug policy (2015). This study is concerned with whether one’s attitude toward addiction and one’s knowledge about cocaine are related to opinions about sentencing for drug crimes and particularly different sentencing for crack and cocaine offenses.
  • Ray Abundance and Diversity in the Satilla Rive

    Silliman, Brennan; Augusta State University Honors Thesis; Augusta State University Honors Thesis (Augusta University, 2021)
    Over the past 100 years, the Satilla River has been cut several times for logging and navigational purposes. The most notable cut is Noyes Cut, located adjacent to Umbrella and Dover Creeks. Due to changes in local economic pursuits, Noyes Cut is not used except by a few local fishermen and has potentially altered water flow and salinity gradients. Ultimately, this affects habitats of animals, such as rays. The Satilla River is home to 52 different kinds of species of saltwater and freshwater fish. These include sunfish, sharks, catfish, seatrout, and tarpon (Kenakrow, 2020). Rays are found worldwide and are the most diverse of cartilaginous fish; they play a vital role in determining the health of an ecosystem by influencing/controlling where certain fish, mollusk, and crustacean populations are. Rays can indicate if an ecosystem is in distress. Four locations in the Satilla River were sampled using experimental gill nets, otter trawls, and a multi-parameter water quality probe from July 2014 through September 2019. All rays were identified by species with total length and disc width recorded to the nearest centimeter (cm). At least 3 species of rays (possibly more), which include the Atlantic Stingray, the Smooth Butterfly Ray, and the Southern Stingray, call this area home. Additionally, this five year data set will be compared to a creel survey currently being conducted on the Satilla River. We hope to make comparisons between our 2018-2019 sampling year and the 2019-2020 creel survey. Since rays are an indicator species, it may be possible to determine if they’ve been affected by Noyes Cut. Noyes Cut was originally constructed around 1910 as a way for Edward Noyes to float logs to his lumber mill business. He used this waterway until 1933 when the U.S. Army Corps seized it and deepened the cut as an inland waterway. Over several decades, channel sedimentation has gradually affected salinity gradients which ultimately altered the natural water circulation patterns within the estuary.
  • Music Composition Using Romantic and Contemporary Techniques Reflection Paper

    Kenison, Caitlin; Augusta State University Honors Thesis; Augusta State University Honors Thesis (Augusta University, 2021)

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