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Comparative study of ventrogluteal and dorsogluteal sites on pain following intramuscular injectionThe purpose of this study was to compare the incidence, severity, and duration of reported pain following the administration of · sterile water (2cc) by intramuscular injection into the ventrogluteal and dorsogluteal sites. The sample consisted of 16 adult healthy volunteers. Subjects received a single injection of sterile water at each site in a cross-over fashion. lmmedia~ely following the injection and· at specific time intervals the subjects rated their pain utilizing a· visual analog (VAS) and verbal descriptor (VDS) scale. T-test for dependent samples revealed differences (Jl.=.015) between the sites in the incidence of pain overall assessed by VDS. Two-way ANOVA showed differences (g,=.0001 to g,=.0007) for site and time for the severity of pain overall assessed by bo_th scales. Chi-Square test revealed differences (g,=.028) for 15 min. and (g,=.049) for 720 min. time intervals assessed by VDS and VAS respectively. The dorsogluteal site was reported by the participants to be less painful.
A comparison of two splinting techniques for osteoarthritis of the thumb carpometacarpal joinEffects of two hand-based splint designs were compared regarding thumb pain, pinch strength, hand function, and splint satisfaction in subjects 1with thumb carpometacarpal (CMC) I joint osteoarthritis. Thirty subjects were treated with a prefabricated soft neoprene splint or a rigid custom-made Aquaplast splint worn during hand function for approximately four weeks. Subjects were tested pre- and post-treatment for thumb pain during hand function, pain while pinching, pinch strength with and without splint we'!,r, hand function, and splint satisfaction. The rigid splint differed significantly in improving thumb pain during function, whereas neither splint proved more effective in improving remaining factors pre- to post-treatment, nor was either more satisfying statistically. During post-treatment measurements, wearing a rigid splint was more effective in reducing pain during pinch and pinch strength measurements. Finally, splinting as a whole improved thumb symptoms over Hme except pinch strength.
Cytoprotective and cognitive enhancing properties of JWB1-84-1JWB 1-84-1 is one of 50 tertiary amine analogs of choline synthesized with the expectation that they would be high potency compounds for cytoprotection. As one of the more potent analogs in this regard, JWB 1-84-1, a piperazine derivative, was selected for testing as a cognition-enhancing agent. The compound was evaluated for efficacy in Alzheimer's disease transgenic mice (B6C3-Tg(APPswe, PSENldE9)85Dbo/J). The mice (AJ? Tg) were first subjected t9 a behavioral test battery in which the transgenic strain was compared with the wild-type strain. AD Tg mice were shown to exhibit specific deficits in the acquisition of a working memory (radial arm water maze) task at a time when the animals exhibited maximal cerebral amyloid plaque burden. JWB 1-84-1 produced a dose-dependent decrease in the number of errors.made by well trained AD-Tg mice in a 5-trial/session radial arm water maze task that was maximal after the 20 μg/kg dose. Aged macaques (20-32 y) were trained to proficiency in their performance of a . computer-assisted delayed matching-to-sample task. Vehicle (normal saline) or JWB 1- 84-1 (5-150 ~tg/kg, i.m.) w~s adip.inistered 10 min before the initiating of testing. On average, JWB 1-84-1 treatment significantly improved task accuracy after all but-the lowest dose. JWB 1-84-1 showed cytoprotection in .a dose dependent manner in NGF withdrawal model of cytotoxicity in differentiated PC-12 cells. Additionally, JWBl-84- 1, at the high concentrat~on caused increase in intracellular Ca + 2 in primary cultured hippocampal as well as cortical neurons by acting di;ectly ~n an intracellular Ca +2 . store. Thus JWB 1-84-1 exhibits th~ potential for treating the cognitive symptoms associated with neurodegenerativ~ diseases and attention deficit disorders. Its cytoprotective action also might work to slow the progression of neurodegenerative diseases such as Alzheimer's disease.
Teaching Matters July 2020Table of Contents: Transparency in Learning and Teaching (TILT), IPSO clients research why elderly people are more susceptible to COVID-19, ISC Prepares for a Return to Face-to-Face Instruction, Greenblatt Library receives funding to develop data literacy training modules, Student Updates (Record Number of Honors Students Published, Scholars Present Research in a Virtual Symposium, Study Abroad 2021 Programs, AAMI Mentoring, JAG Pals Providing Real Support in Virtual Times, Does Your Department Need a Student Worker?)