Welcome to Scholarly Commons, the institutional repository for Augusta University.

 

 

The University Libraries offer advisory support to faculty who want to create open access journal publications or have questions regarding copyright, author rights, and publisher contracts.  Individuals may submit scholarly works or departments may submit a collection of works. Additional information about Scholarly Commons can be found on this Research Guide.

  • From Adipokines to Atherosclerosis: the role of adipose tissue in inflammation and etiology of vascular disease

    Bundy, Vanessa; Medical College of Georgia (Augusta University, 2007-04)
    The prevalence of overweight and obese ha.s ·steadily increased over the years among males and females of all ages, all racial and ethnic groups, and all . ;. educational levels. Recent . studies have established adipose tissue as a dynamic, endocrine organ with th_e capacity to secrete a number of adipokines which may act direct_ly upon the vasculature to stimulate adhesion molecule expression and·" exacerbate -vascular dis·ea:se. Our aim was to elucidate the associations of vasoactive pro- and anti- inflammatory factors, including adhesion molecules, with adiposity, blood pressure and endothelial function, and to distinguish race and sex variations in these relationships. To accomplish this, we expanded upon existing measurements within a Georgia Prevention Institute cross-sectional study entitled Lifestyle, Adiposity & Cardiovascular t-Jealth in Youths (LACHY) by adding two cardiovascular disease risk factor domains: inflammation and vascular adhesion. Our model included measurements of adiposity, adiponectin,. C-reactive protein, leptin, insulin, resistin, tumor necrosis factor-a, interleukin-6, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, blood pressure and endothelial-dependent arterial dilation.·· Our findings include numerous race and sex differences in the concentration of circulating risk factors along with. significant interactions between them and measurements of adiposity. However, we did not find circulating cardiovascular disease risk factors or their concentration differences to be significantly associated with blood pressure or endothelial function. We believe this to be largely due to the fact that our subject. were young and apparently healthy at time of measurement. Overall, findings provide insight into the relationships between adiposity, inflammation and cardiovascular outcomes· in black and· white, male and female adolescents. Future studies are needed to further elucidate these relationships and mow they may change. over time.
  • Evidence supporting glial derived TGF-βı as a modulator of luteinizing hormone-releasing hormone

    Buchanan, Clint D.; Medical College of Georgia (Augusta University, 2000-03)
  • Gallium uptake and substantivity on dentin, in vitro

    Bruce, William F., Jr.; Medical College of Georgia (Augusta University, 1996-02)

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