An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Properties

Hdl Handle:
http://hdl.handle.net/10675.2/817
Title:
An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Properties
Authors:
Gong, Shi-qiang; Epasinghe, Jeevani; Rueggeberg, Frederick A.; Niu, Li-na; Mettenberg, Donald; Yiu, Cynthia K. Y.; Blizzard, John D.; Wu, Christine D.; Mao, Jing; Drisko, Connie L.; Pashley, David H.; Tay, Franklin R.
Abstract:
Global increase in patients seeking orthodontic treatment creates a demand for the use of acrylic resins in removable appliances and retainers. Orthodontic removable appliance wearers have a higher risk of oral infections that are caused by the formation of bacterial and fungal biofilms on the appliance surface. Here, we present the synthetic route for an antibacterial and antifungal organically-modified silicate (ORMOSIL) that has multiple methacryloloxy functionalities attached to a siloxane backbone (quaternary ammonium methacryloxy silicate, or QAMS). By dissolving the water-insoluble, rubbery ORMOSIL in methyl methacrylate, QAMS may be copolymerized with polymethyl methacrylate, and covalently incorporated in the pressure-processed acrylic resin. The latter demonstrated a predominantly contact-killing effect on Streptococcus mutans ATCC 36558 and Actinomyces naselundii ATCC 12104 biofilms, while inhibiting adhesion of Candida albicans ATCC 90028 on the acrylic surface. Apart from its favorable antimicrobial activities, QAMS-containing acrylic resins exhibited decreased water wettability and improved toughness, without adversely affecting the flexural strength and modulus, water sorption and solubility, when compared with QAMS-free acrylic resin. The covalently bound, antimicrobial orthodontic acrylic resin with improved toughness represents advancement over other experimental antimicrobial acrylic resin formulations, in its potential to simultaneously prevent oral infections during appliance wear, and improve the fracture resistance of those appliances.
Citation:
PLoS One. 2012 Aug 1; 7(8):e42355
Issue Date:
1-Aug-2012
URI:
http://hdl.handle.net/10675.2/817
DOI:
10.1371/journal.pone.0042355
PubMed ID:
22870322
PubMed Central ID:
PMC3411672
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Department of Oral Biology Faculty Papers

Full metadata record

DC FieldValue Language
dc.contributor.authorGong, Shi-qiangen_US
dc.contributor.authorEpasinghe, Jeevanien_US
dc.contributor.authorRueggeberg, Frederick A.en_US
dc.contributor.authorNiu, Li-naen_US
dc.contributor.authorMettenberg, Donalden_US
dc.contributor.authorYiu, Cynthia K. Y.en_US
dc.contributor.authorBlizzard, John D.en_US
dc.contributor.authorWu, Christine D.en_US
dc.contributor.authorMao, Jingen_US
dc.contributor.authorDrisko, Connie L.en_US
dc.contributor.authorPashley, David H.en_US
dc.contributor.authorTay, Franklin R.en_US
dc.date.accessioned2012-10-26T20:35:10Z-
dc.date.available2012-10-26T20:35:10Z-
dc.date.issued2012-08-01en_US
dc.identifier.citationPLoS One. 2012 Aug 1; 7(8):e42355en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid22870322en_US
dc.identifier.doi10.1371/journal.pone.0042355en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/817-
dc.description.abstractGlobal increase in patients seeking orthodontic treatment creates a demand for the use of acrylic resins in removable appliances and retainers. Orthodontic removable appliance wearers have a higher risk of oral infections that are caused by the formation of bacterial and fungal biofilms on the appliance surface. Here, we present the synthetic route for an antibacterial and antifungal organically-modified silicate (ORMOSIL) that has multiple methacryloloxy functionalities attached to a siloxane backbone (quaternary ammonium methacryloxy silicate, or QAMS). By dissolving the water-insoluble, rubbery ORMOSIL in methyl methacrylate, QAMS may be copolymerized with polymethyl methacrylate, and covalently incorporated in the pressure-processed acrylic resin. The latter demonstrated a predominantly contact-killing effect on Streptococcus mutans ATCC 36558 and Actinomyces naselundii ATCC 12104 biofilms, while inhibiting adhesion of Candida albicans ATCC 90028 on the acrylic surface. Apart from its favorable antimicrobial activities, QAMS-containing acrylic resins exhibited decreased water wettability and improved toughness, without adversely affecting the flexural strength and modulus, water sorption and solubility, when compared with QAMS-free acrylic resin. The covalently bound, antimicrobial orthodontic acrylic resin with improved toughness represents advancement over other experimental antimicrobial acrylic resin formulations, in its potential to simultaneously prevent oral infections during appliance wear, and improve the fracture resistance of those appliances.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectMicrobiologyen_US
dc.subjectBacteriologyen_US
dc.subjectBacterial Biofilmsen_US
dc.subjectChemistryen_US
dc.subjectChemical Reactionsen_US
dc.subjectOrganic Reactionsen_US
dc.subjectPolymerizationen_US
dc.subjectPolymerizationen_US
dc.subjectOrganic Chemistryen_US
dc.subjectOrganic Reactionsen_US
dc.subjectPolymerizationen_US
dc.subjectPolymer Chemistryen_US
dc.subjectPolymerizationen_US
dc.subjectMaterials Scienceen_US
dc.subjectMaterial by Structureen_US
dc.subjectPolymersen_US
dc.subjectSynthetic Polymersen_US
dc.subjectMedicineen_US
dc.subjectOral Medicineen_US
dc.subjectDentistryen_US
dc.titleAn ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Propertiesen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3411672en_US
dc.contributor.corporatenameDepartment of Oral Biology-
dc.contributor.corporatenameDepartment of Oral Rehabilitation-

Related articles on PubMed

All Items in Scholarly Commons are protected by copyright, with all rights reserved, unless otherwise indicated.