Aortic Calcification and Femoral Bone Density Are Independently Associated with Left Ventricular Mass in Patients with Chronic Kidney Disease

Hdl Handle:
http://hdl.handle.net/10675.2/799
Title:
Aortic Calcification and Femoral Bone Density Are Independently Associated with Left Ventricular Mass in Patients with Chronic Kidney Disease
Authors:
Chue, Colin D.; Wall, Nadezhda A.; Crabtree, Nicola J.; Zehnder, Daniel; Moody, William E.; Edwards, Nicola C.; Steeds, Richard P.; Townend, Jonathan N.; Ferro, Charles J. ( 0000-0003-0577-7081 )
Abstract:
Background: Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown. We assessed the relationship between vascular calcification, femoral bone density and left ventricular mass in patients with stage 3 non-diabetic chronic kidney disease in a cross-sectional observational study.; Methodology and Principal Findings: A total of 120 patients were recruited (54% male, mean age 55(+/-)14 years, mean glomerular filtration rate 50(+/-)13 ml/min/1.73 m2). Abdominal aortic calcification was assessed using lateral lumbar spine radiography and was present in 48%. Mean femoral Z-score measured using dual energy x-ray absorptiometry was 0.60(+/-)1.06. Cardiovascular magnetic resonance imaging was used to determine left ventricular mass. One patient had left ventricular hypertrophy. Subjects with aortic calcification had higher left ventricular mass compared to those without (56(+/-)16 vs. 48(+/-)12 g/m2, P = 0.002), as did patients with femoral Z-scores below zero (56(+/-)15 vs. 49(+/-)13 g/m2, P = 0.01). In univariate analysis presence of aortic calcification correlated with left ventricular mass (r = 0.32, P = 0.001); mean femoral Zscore inversely correlated with left ventricular mass (r =20.28, P = 0.004). In a multivariate regression model that included presence of aortic calcification, mean femoral Z-score, gender and 24-hour systolic blood pressure, 46% of the variability in left ventricular mass was explained (P<0.001).; Conclusions: In patients with stage 3 non-diabetic chronic kidney disease, lower mean femoral Z-score and presence of aortic calcification are independently associated with increased left ventricular mass. Further research exploring the pathophysiology that underlies these relationships is warranted.
Editors:
Shi, Xing-Ming
Citation:
PLoS One. 2012 Jun 18; 7(6):e39241
Issue Date:
18-Jun-2012
URI:
http://hdl.handle.net/10675.2/799
DOI:
10.1371/journal.pone.0039241
PubMed ID:
22723973
PubMed Central ID:
PMC3377619
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Department of Pathology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorChue, Colin D.en_US
dc.contributor.authorWall, Nadezhda A.en_US
dc.contributor.authorCrabtree, Nicola J.en_US
dc.contributor.authorZehnder, Danielen_US
dc.contributor.authorMoody, William E.en_US
dc.contributor.authorEdwards, Nicola C.en_US
dc.contributor.authorSteeds, Richard P.en_US
dc.contributor.authorTownend, Jonathan N.en_US
dc.contributor.authorFerro, Charles J.en_US
dc.contributor.editorShi, Xing-Ming-
dc.date.accessioned2012-10-26T20:30:46Z-
dc.date.available2012-10-26T20:30:46Z-
dc.date.issued2012-06-18en_US
dc.identifier.citationPLoS One. 2012 Jun 18; 7(6):e39241en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid22723973en_US
dc.identifier.doi10.1371/journal.pone.0039241en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/799-
dc.description.abstractBackground: Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown. We assessed the relationship between vascular calcification, femoral bone density and left ventricular mass in patients with stage 3 non-diabetic chronic kidney disease in a cross-sectional observational study.en_US
dc.description.abstractMethodology and Principal Findings: A total of 120 patients were recruited (54% male, mean age 55(+/-)14 years, mean glomerular filtration rate 50(+/-)13 ml/min/1.73 m2). Abdominal aortic calcification was assessed using lateral lumbar spine radiography and was present in 48%. Mean femoral Z-score measured using dual energy x-ray absorptiometry was 0.60(+/-)1.06. Cardiovascular magnetic resonance imaging was used to determine left ventricular mass. One patient had left ventricular hypertrophy. Subjects with aortic calcification had higher left ventricular mass compared to those without (56(+/-)16 vs. 48(+/-)12 g/m2, P = 0.002), as did patients with femoral Z-scores below zero (56(+/-)15 vs. 49(+/-)13 g/m2, P = 0.01). In univariate analysis presence of aortic calcification correlated with left ventricular mass (r = 0.32, P = 0.001); mean femoral Zscore inversely correlated with left ventricular mass (r =20.28, P = 0.004). In a multivariate regression model that included presence of aortic calcification, mean femoral Z-score, gender and 24-hour systolic blood pressure, 46% of the variability in left ventricular mass was explained (P<0.001).en_US
dc.description.abstractConclusions: In patients with stage 3 non-diabetic chronic kidney disease, lower mean femoral Z-score and presence of aortic calcification are independently associated with increased left ventricular mass. Further research exploring the pathophysiology that underlies these relationships is warranted.en_US
dc.rightsChue et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectAnatomy and Physiologyen_US
dc.subjectMusculoskeletal Systemen_US
dc.subjectBoneen_US
dc.subjectBiochemistryen_US
dc.subjectMetabolismen_US
dc.subjectBone and Mineral Metabolismen_US
dc.subjectMedicineen_US
dc.subjectCardiovascularen_US
dc.subjectAortic Diseasesen_US
dc.subjectCardiovascular Imagingen_US
dc.subjectHypertensionen_US
dc.subjectClinical Research Designen_US
dc.subjectObservational Studiesen_US
dc.subjectNephrologyen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectMineral Metabolism and the Kidneyen_US
dc.subjectRadiologyen_US
dc.subjectDiagnostic Radiologyen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.titleAortic Calcification and Femoral Bone Density Are Independently Associated with Left Ventricular Mass in Patients with Chronic Kidney Diseaseen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3377619en_US
dc.contributor.corporatenameDepartment of Pathology-
dc.contributor.corporatenameCollege of Graduate Studies-

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