Hdl Handle:
http://hdl.handle.net/10675.2/774
Title:
Promotion of plasma membrane repair by vitamin E
Authors:
Howard, Amber Cyran; McNeil, Anna K.; McNeil, Paul L.
Abstract:
Severe vitamin E deficiency results in lethal myopathy in animal models. Membrane repair is an important myocyte response to plasma membrane disruption injury as when repair fails, myocytes die and muscular dystrophy ensues. Here we show that supplementation of cultured cells with α-tocopherol, the most common form of vitamin E, promotes plasma membrane repair. Conversely, in the absence of α-tocopherol supplementation, exposure of cultured cells to an oxidant challenge strikingly inhibits repair. Comparative measurements reveal that, to promote repair, an anti-oxidant must associate with membranes, as α-tocopherol does, or be capable of α-tocopherol regeneration. Finally, we show that myocytes in intact muscle cannot repair membranes when exposed to an oxidant challenge, but show enhanced repair when supplemented with vitamin E. Our work suggests a novel biological function for vitamin E in promoting myocyte plasma membrane repair. We propose that this function is essential for maintenance of skeletal muscle homeostasis.
Citation:
Nat Commun. 2011 Dec 20; 2:597
Issue Date:
20-Dec-2011
URI:
http://hdl.handle.net/10675.2/774
DOI:
10.1038/ncomms1594
PubMed ID:
22186893
PubMed Central ID:
PMC3247818
Type:
Article
ISSN:
2041-1723
Appears in Collections:
Institute of Molecular Medicine and Genetics: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorHoward, Amber Cyranen_US
dc.contributor.authorMcNeil, Anna K.en_US
dc.contributor.authorMcNeil, Paul L.en_US
dc.date.accessioned2012-10-26T20:30:42Z-
dc.date.available2012-10-26T20:30:42Z-
dc.date.issued2011-12-20en_US
dc.identifier.citationNat Commun. 2011 Dec 20; 2:597en_US
dc.identifier.issn2041-1723en_US
dc.identifier.pmid22186893en_US
dc.identifier.doi10.1038/ncomms1594en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/774-
dc.description.abstractSevere vitamin E deficiency results in lethal myopathy in animal models. Membrane repair is an important myocyte response to plasma membrane disruption injury as when repair fails, myocytes die and muscular dystrophy ensues. Here we show that supplementation of cultured cells with α-tocopherol, the most common form of vitamin E, promotes plasma membrane repair. Conversely, in the absence of α-tocopherol supplementation, exposure of cultured cells to an oxidant challenge strikingly inhibits repair. Comparative measurements reveal that, to promote repair, an anti-oxidant must associate with membranes, as α-tocopherol does, or be capable of α-tocopherol regeneration. Finally, we show that myocytes in intact muscle cannot repair membranes when exposed to an oxidant challenge, but show enhanced repair when supplemented with vitamin E. Our work suggests a novel biological function for vitamin E in promoting myocyte plasma membrane repair. We propose that this function is essential for maintenance of skeletal muscle homeostasis.en_US
dc.rightsCopyright © 2011, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.en_US
dc.titlePromotion of plasma membrane repair by vitamin Een_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3247818en_US
dc.contributor.corporatenameInstitute of Molecular Medicine and Genetics-
dc.contributor.corporatenameDepartment of Cellular Biology and Anatomy-

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