Intraoperative neurocytology of primary central nervous system neoplasia: A simplified and practical diagnostic approach

Hdl Handle:
http://hdl.handle.net/10675.2/766
Title:
Intraoperative neurocytology of primary central nervous system neoplasia: A simplified and practical diagnostic approach
Authors:
Sharma, Suash; Deb, Prabal
Abstract:
Intraoperative consultations may pose considerable diagnostic challenge to the neuropathologist in diagnosing primary and metastatic neoplasms of the central nervous system (CNS). Cytological preparations in the form of squash, touch, imprint or smears are few of the available modalities in addition to the frozen section (FS). Although the latter is superior in providing both histologic patterns and cytomorphologic details yet smears are of vital importance when tissue available is limited (stereotactic biopsy), scrutinisation of intercellular matrix (astrocytoma versus oligodendroglioma) and evaluation of discohesive cells (lymphoma, pituitary adenoma) and in inflammatory lesions. This review is intended to emphasize the value, applicability and limitations of neurocytology aiming to expedite the intraoperative smear-based diagnoses of CNS neoplasia as per the World Health Organization (WHO) classification. We recommend that whenever possible, both smears and FS should be examined concomitantly and in a correlative manner. In the unlikely event of a mismatch between the findings on smear and FS, intraoperative diagnosis is primarily based on FS, if adequate tissue is available. However, each case must be evaluated on its own merit and in difficult cases relevant differential diagnoses should be offered to facilitate surgical decisions and optimally triage patient management.
Citation:
J Cytol. 2011 Oct-Dec; 28(4):147-158
Issue Date:
2011
URI:
http://hdl.handle.net/10675.2/766
DOI:
10.4103/0970-9371.86339
PubMed ID:
22090687
PubMed Central ID:
PMC3214458
Type:
Article
ISSN:
0974-5165
Appears in Collections:
Department of Pathology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorSharma, Suashen_US
dc.contributor.authorDeb, Prabalen_US
dc.date.accessioned2012-10-26T20:30:41Z-
dc.date.available2012-10-26T20:30:41Z-
dc.date.issued2011en_US
dc.identifier.citationJ Cytol. 2011 Oct-Dec; 28(4):147-158en_US
dc.identifier.issn0974-5165en_US
dc.identifier.pmid22090687en_US
dc.identifier.doi10.4103/0970-9371.86339en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/766-
dc.description.abstractIntraoperative consultations may pose considerable diagnostic challenge to the neuropathologist in diagnosing primary and metastatic neoplasms of the central nervous system (CNS). Cytological preparations in the form of squash, touch, imprint or smears are few of the available modalities in addition to the frozen section (FS). Although the latter is superior in providing both histologic patterns and cytomorphologic details yet smears are of vital importance when tissue available is limited (stereotactic biopsy), scrutinisation of intercellular matrix (astrocytoma versus oligodendroglioma) and evaluation of discohesive cells (lymphoma, pituitary adenoma) and in inflammatory lesions. This review is intended to emphasize the value, applicability and limitations of neurocytology aiming to expedite the intraoperative smear-based diagnoses of CNS neoplasia as per the World Health Organization (WHO) classification. We recommend that whenever possible, both smears and FS should be examined concomitantly and in a correlative manner. In the unlikely event of a mismatch between the findings on smear and FS, intraoperative diagnosis is primarily based on FS, if adequate tissue is available. However, each case must be evaluated on its own merit and in difficult cases relevant differential diagnoses should be offered to facilitate surgical decisions and optimally triage patient management.en_US
dc.rightsCopyright: © Journal of Cytologyen_US
dc.subjectReview Articleen_US
dc.titleIntraoperative neurocytology of primary central nervous system neoplasia: A simplified and practical diagnostic approachen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3214458en_US
dc.contributor.corporatenameDepartment of Pathology-

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