Hdl Handle:
http://hdl.handle.net/10675.2/765
Title:
The Role of Uridine Adenosine Tetraphosphate in the Vascular System
Authors:
Matsumoto, Takayuki; Tostes, Rita C.; Webb, R. Clinton
Abstract:
The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.
Citation:
Adv Pharmacol Sci. 2011 Nov 1; 2011:435132
Issue Date:
1-Nov-2011
URI:
http://hdl.handle.net/10675.2/765
DOI:
10.1155/2011/435132
PubMed ID:
22110488
PubMed Central ID:
PMC3206368
Type:
Article
ISSN:
1687-6342
Appears in Collections:
Department of Physiology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorMatsumoto, Takayukien_US
dc.contributor.authorTostes, Rita C.en_US
dc.contributor.authorWebb, R. Clintonen_US
dc.date.accessioned2012-10-26T20:30:41Z-
dc.date.available2012-10-26T20:30:41Z-
dc.date.issued2011-11-1en_US
dc.identifier.citationAdv Pharmacol Sci. 2011 Nov 1; 2011:435132en_US
dc.identifier.issn1687-6342en_US
dc.identifier.pmid22110488en_US
dc.identifier.doi10.1155/2011/435132en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/765-
dc.description.abstractThe endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.en_US
dc.rightsCopyright © 2011 Takayuki Matsumoto et al.en_US
dc.subjectReview Articleen_US
dc.titleThe Role of Uridine Adenosine Tetraphosphate in the Vascular Systemen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3206368en_US
dc.contributor.corporatenameDepartment of Physiology-

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