Carcinomatous Meningitis: The Natural History of Successfully Treated Metastatic Bladder Cancer

Hdl Handle:
http://hdl.handle.net/10675.2/757
Title:
Carcinomatous Meningitis: The Natural History of Successfully Treated Metastatic Bladder Cancer
Authors:
Tadepalli, S.; Coleman, Teresa; Hackett, Ladawn A.; Liles, G.B.
Abstract:
Carcinomatous meningitis due to bladder cancer is a rare entity reported only in case reports. Optimal therapy is thus poorly defined with earlier cases reporting an unsuccessful outcome. Here we report a case of late carcinomatous meningitis secondary to transitional cell carcinoma (TCC) of the bladder occurring in a patient in complete remission. He was successfully treated with intrathecal methotrexate and whole brain irradiation and experienced prolonged survival after treatment. With modern chemotherapy increasing complete remissions and survival rates in patients with TCC, more and more patients are being reported with carcinomatous meningitis. We raise the question of whether central nervous system prophylaxis should be considered in patients with TCC achieving a complete remission to chemotherapy in the metastatic setting.; Key words: Carcinomatous meningitis
Citation:
Case Rep Oncol. 2011 Aug 24; 4(2):406-412
Issue Date:
24-Aug-2011
URI:
http://hdl.handle.net/10675.2/757
DOI:
10.1159/000331263
PubMed ID:
21941490
PubMed Central ID:
PMC3177797
Type:
Article
ISSN:
1662-6575
Appears in Collections:
Department of Medicine Faculty: Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorTadepalli, S.en_US
dc.contributor.authorColeman, Teresaen_US
dc.contributor.authorHackett, Ladawn A.en_US
dc.contributor.authorLiles, G.B.en_US
dc.date.accessioned2012-10-26T20:28:41Z-
dc.date.available2012-10-26T20:28:41Z-
dc.date.issued2011-08-24en_US
dc.identifier.citationCase Rep Oncol. 2011 Aug 24; 4(2):406-412en_US
dc.identifier.issn1662-6575en_US
dc.identifier.pmid21941490en_US
dc.identifier.doi10.1159/000331263en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/757-
dc.description.abstractCarcinomatous meningitis due to bladder cancer is a rare entity reported only in case reports. Optimal therapy is thus poorly defined with earlier cases reporting an unsuccessful outcome. Here we report a case of late carcinomatous meningitis secondary to transitional cell carcinoma (TCC) of the bladder occurring in a patient in complete remission. He was successfully treated with intrathecal methotrexate and whole brain irradiation and experienced prolonged survival after treatment. With modern chemotherapy increasing complete remissions and survival rates in patients with TCC, more and more patients are being reported with carcinomatous meningitis. We raise the question of whether central nervous system prophylaxis should be considered in patients with TCC achieving a complete remission to chemotherapy in the metastatic setting.en_US
dc.description.abstractKey words: Carcinomatous meningitisen_US
dc.rightsCopyright © 2011 by S. Karger AG, Baselen_US
dc.subjectPublished: August 2011en_US
dc.titleCarcinomatous Meningitis: The Natural History of Successfully Treated Metastatic Bladder Canceren_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3177797en_US
dc.contributor.corporatenameDepartment of Medicine-
dc.contributor.corporatenameDepartment of Pathology-
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