NMDA Receptors Are Not Required for Pattern Completion During Associative Memory Recall

Hdl Handle:
http://hdl.handle.net/10675.2/738
Title:
NMDA Receptors Are Not Required for Pattern Completion During Associative Memory Recall
Authors:
Mei, Bing; Li, Fei; Gu, Yiran; Cui, Zhenzhong; Tsien, Joe Z.
Abstract:
Pattern completion, the ability to retrieve complete memories initiated by subsets of external cues, has been a major focus of many computation models. A previously study reports that such pattern completion requires NMDA receptors in the hippocampus. However, such a claim was derived from a non-inducible gene knockout experiment in which the NMDA receptors were absent throughout all stages of memory processes as well as animal's adult life. This raises the critical question regarding whether the previously described results were truly resulting from the requirement of the NMDA receptors in retrieval. Here, we have examined the role of the NMDA receptors in pattern completion via inducible knockout of NMDA receptors limited to the memory retrieval stage. By using two independent mouse lines, we found that inducible knockout mice, lacking NMDA receptor in either forebrain or hippocampus CA1 region at the time of memory retrieval, exhibited normal recall of associative spatial reference memory regardless of whether retrievals took place under full-cue or partial-cue conditions. Moreover, systemic antagonism of NMDA receptor during retention tests also had no effect on full-cue or partial-cue recall of spatial water maze memories. Thus, both genetic and pharmacological experiments collectively demonstrate that pattern completion during spatial associative memory recall does not require the NMDA receptor in the hippocampus or forebrain.
Citation:
PLoS One. 2011 Apr 29; 6(4):e19326
Issue Date:
29-Apr-2011
URI:
http://hdl.handle.net/10675.2/738
DOI:
10.1371/journal.pone.0019326
PubMed ID:
21559402
PubMed Central ID:
PMC3084823
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Brain & Behavior Discovery Institute: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorMei, Bingen_US
dc.contributor.authorLi, Feien_US
dc.contributor.authorGu, Yiranen_US
dc.contributor.authorCui, Zhenzhongen_US
dc.contributor.authorTsien, Joe Z.en_US
dc.date.accessioned2012-10-26T20:27:53Z-
dc.date.available2012-10-26T20:27:53Z-
dc.date.issued2011-04-29en_US
dc.identifier.citationPLoS One. 2011 Apr 29; 6(4):e19326en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid21559402en_US
dc.identifier.doi10.1371/journal.pone.0019326en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/738-
dc.description.abstractPattern completion, the ability to retrieve complete memories initiated by subsets of external cues, has been a major focus of many computation models. A previously study reports that such pattern completion requires NMDA receptors in the hippocampus. However, such a claim was derived from a non-inducible gene knockout experiment in which the NMDA receptors were absent throughout all stages of memory processes as well as animal's adult life. This raises the critical question regarding whether the previously described results were truly resulting from the requirement of the NMDA receptors in retrieval. Here, we have examined the role of the NMDA receptors in pattern completion via inducible knockout of NMDA receptors limited to the memory retrieval stage. By using two independent mouse lines, we found that inducible knockout mice, lacking NMDA receptor in either forebrain or hippocampus CA1 region at the time of memory retrieval, exhibited normal recall of associative spatial reference memory regardless of whether retrievals took place under full-cue or partial-cue conditions. Moreover, systemic antagonism of NMDA receptor during retention tests also had no effect on full-cue or partial-cue recall of spatial water maze memories. Thus, both genetic and pharmacological experiments collectively demonstrate that pattern completion during spatial associative memory recall does not require the NMDA receptor in the hippocampus or forebrain.en_US
dc.rightsMei et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectNeuroscienceen_US
dc.subjectAnimal Cognitionen_US
dc.subjectBehavioral Neuroscienceen_US
dc.subjectLearning and Memoryen_US
dc.subjectNeuropsychologyen_US
dc.subjectNeurotransmittersen_US
dc.titleNMDA Receptors Are Not Required for Pattern Completion During Associative Memory Recallen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3084823en_US
dc.contributor.corporatenameBrain & Behavior Discovery Institute-
dc.contributor.corporatenameDepartment of Neurology-

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