Convergent Processing of Both Positive and Negative Motivational Signals by the VTA Dopamine Neuronal Populations

Hdl Handle:
http://hdl.handle.net/10675.2/734
Title:
Convergent Processing of Both Positive and Negative Motivational Signals by the VTA Dopamine Neuronal Populations
Authors:
Wang, Dong V.; Tsien, Joe Z.
Abstract:
Dopamine neurons in the ventral tegmental area (VTA) have been traditionally studied for their roles in reward-related motivation or drug addiction. Here we study how the VTA dopamine neuron population may process fearful and negative experiences as well as reward information in freely behaving mice. Using multi-tetrode recording, we find that up to 89% of the putative dopamine neurons in the VTA exhibit significant activation in response to the conditioned tone that predict food reward, while the same dopamine neuron population also respond to the fearful experiences such as free fall and shake events. The majority of these VTA putative dopamine neurons exhibit suppression and offset-rebound excitation, whereas ~25% of the recorded putative dopamine neurons show excitation by the fearful events. Importantly, VTA putative dopamine neurons exhibit parametric encoding properties: their firing change durations are proportional to the fearful event durations. In addition, we demonstrate that the contextual information is crucial for these neurons to respectively elicit positive or negative motivational responses by the same conditioned tone. Taken together, our findings suggest that VTA dopamine neurons may employ the convergent encoding strategy for processing both positive and negative experiences, intimately integrating with cues and environmental context.
Citation:
PLoS One. 2011 Feb 15; 6(2):e17047
Issue Date:
15-Feb-2011
URI:
http://hdl.handle.net/10675.2/734
DOI:
10.1371/journal.pone.0017047
PubMed ID:
21347237
PubMed Central ID:
PMC3039659
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Brain & Behavior Discovery Institute: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Dong V.en_US
dc.contributor.authorTsien, Joe Z.en_US
dc.date.accessioned2012-10-26T20:27:15Z-
dc.date.available2012-10-26T20:27:15Z-
dc.date.issued2011-02-15en_US
dc.identifier.citationPLoS One. 2011 Feb 15; 6(2):e17047en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid21347237en_US
dc.identifier.doi10.1371/journal.pone.0017047en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/734-
dc.description.abstractDopamine neurons in the ventral tegmental area (VTA) have been traditionally studied for their roles in reward-related motivation or drug addiction. Here we study how the VTA dopamine neuron population may process fearful and negative experiences as well as reward information in freely behaving mice. Using multi-tetrode recording, we find that up to 89% of the putative dopamine neurons in the VTA exhibit significant activation in response to the conditioned tone that predict food reward, while the same dopamine neuron population also respond to the fearful experiences such as free fall and shake events. The majority of these VTA putative dopamine neurons exhibit suppression and offset-rebound excitation, whereas ~25% of the recorded putative dopamine neurons show excitation by the fearful events. Importantly, VTA putative dopamine neurons exhibit parametric encoding properties: their firing change durations are proportional to the fearful event durations. In addition, we demonstrate that the contextual information is crucial for these neurons to respectively elicit positive or negative motivational responses by the same conditioned tone. Taken together, our findings suggest that VTA dopamine neurons may employ the convergent encoding strategy for processing both positive and negative experiences, intimately integrating with cues and environmental context.en_US
dc.rightsWang, Tsien. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectNeuroscienceen_US
dc.subjectNeurophysiologyen_US
dc.subjectCentral Nervous Systemen_US
dc.subjectBehavioral Neuroscienceen_US
dc.titleConvergent Processing of Both Positive and Negative Motivational Signals by the VTA Dopamine Neuronal Populationsen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3039659en_US
dc.contributor.corporatenameBrain & Behavior Discovery Institute-
dc.contributor.corporatenameDepartment of Neurology-

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