Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine

Hdl Handle:
http://hdl.handle.net/10675.2/730
Title:
Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine
Authors:
Kuang, Hui; Lin, Longnian; Tsien, Joe Z.
Abstract:
Ketamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period. To understand its effects on neural population dynamics in the brain, we employed large-scale in vivo ensemble recording techniques to monitor the activity patterns of simultaneously recorded hippocampal CA1 pyramidal cells and various interneurons during several conscious and unconscious states such as awake rest, running, slow wave sleep, and ketamine-induced anesthesia. Our analyses reveal that ketamine induces distinct oscillatory dynamics not only in pyramidal cells but also in at least seven different types of CA1 interneurons including putative basket cells, chandelier cells, bistratified cells, and O-LM cells. These emergent unique oscillatory dynamics may very well reflect the intrinsic temporal relationships within the CA1 circuit. It is conceivable that systematic characterization of network dynamics may eventually lead to better understanding of how ketamine induces unconsciousness and consequently alters the conscious mind.
Citation:
PLoS One. 2010 Dec 8; 5(12):e15209
Issue Date:
8-Dec-2010
URI:
http://hdl.handle.net/10675.2/730
DOI:
10.1371/journal.pone.0015209
PubMed ID:
21165147
PubMed Central ID:
PMC2999569
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Brain & Behavior Discovery Institute: Faculty Research and Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKuang, Huien_US
dc.contributor.authorLin, Longnianen_US
dc.contributor.authorTsien, Joe Z.en_US
dc.date.accessioned2012-10-26T20:27:14Z-
dc.date.available2012-10-26T20:27:14Z-
dc.date.issued2010-12-8en_US
dc.identifier.citationPLoS One. 2010 Dec 8; 5(12):e15209en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid21165147en_US
dc.identifier.doi10.1371/journal.pone.0015209en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/730-
dc.description.abstractKetamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period. To understand its effects on neural population dynamics in the brain, we employed large-scale in vivo ensemble recording techniques to monitor the activity patterns of simultaneously recorded hippocampal CA1 pyramidal cells and various interneurons during several conscious and unconscious states such as awake rest, running, slow wave sleep, and ketamine-induced anesthesia. Our analyses reveal that ketamine induces distinct oscillatory dynamics not only in pyramidal cells but also in at least seven different types of CA1 interneurons including putative basket cells, chandelier cells, bistratified cells, and O-LM cells. These emergent unique oscillatory dynamics may very well reflect the intrinsic temporal relationships within the CA1 circuit. It is conceivable that systematic characterization of network dynamics may eventually lead to better understanding of how ketamine induces unconsciousness and consequently alters the conscious mind.en_US
dc.rightsKuang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectAnatomy and Physiologyen_US
dc.subjectElectrophysiologyen_US
dc.subjectModel Organismsen_US
dc.subjectAnimal Modelsen_US
dc.subjectMouseen_US
dc.subjectNeuroscienceen_US
dc.subjectCognitive Neuroscienceen_US
dc.subjectConsciousnessen_US
dc.subjectNeurochemistryen_US
dc.subjectNeurochemicalsen_US
dc.subjectAnimal Cognitionen_US
dc.subjectLearning and Memoryen_US
dc.subjectNeural Networksen_US
dc.subjectNeurophysiologyen_US
dc.subjectNeurotransmittersen_US
dc.subjectMedicineen_US
dc.subjectAnesthesiologyen_US
dc.subjectDrugs and Devicesen_US
dc.subjectBehavioral Pharmacologyen_US
dc.titleTemporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamineen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2999569en_US
dc.contributor.corporatenameBrain & Behavior Discovery Institute-

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