Serum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Function

Hdl Handle:
http://hdl.handle.net/10675.2/715
Title:
Serum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Function
Authors:
Alvarez, Jessica A.; Gower, Barbara A.; Calhoun, David A.; Judd, Suzanne E.; Dong, Yanbin; Dudenbostel, Tanja; Scholl, Jenni; Ashraf, Ambika P. ( 0000-0003-0692-6624 )
Abstract:
Background: Vitamin D reportedly influences vascular function, which is worse in African Americans (AAs) relative to European Americans (EAs). It is not clear if ethnic differences in 25(OH)D mediate differences in vascular function. This study examined the relationships of serum 25-hydroxyvitamin D (25(OH)D) with indicators of vascular function among healthy, young AA and EA adults.; Methods: This is a cross sectional study involving 23 AAs and 22 EAs. The main outcomes were augmentation index (AIx75), central aortic pressure, pulse wave velocity (PWV), flow-mediated dilation (FMD), and seated and supine blood pressures.; Results: Results indicated that 25(OH)D was inversely associated with AIx75, supine systolic blood pressure (SBP), central aortic SBP and central aortic diastolic blood pressure (DBP), independent of age, sex, and percent body fat (standardized β= -0.29 to -0.43, P < 0.05 for all). AAs had greater AIx75 (P = 0.04) and PWV (P = 0.07) and lower FMD (P = 0.02) compared to EA after adjusting for age and percent body fat; further adjustment for 25(OH)D reduced the ethnic differences (P = 0.44, 0.53, and 0.20, respectively).; Conclusion: The 25(OH)D was associated with vascular function in healthy adults, and lower 25(OH)D among AAs may contribute to their greater arterial stiffness and reduced endothelial function (Clinical trials.gov NCT01041365, NCT01041547).
Citation:
J Clin Med Res. 2012 Jun 15; 4(3):197-205
Issue Date:
15-May-2012
URI:
http://hdl.handle.net/10675.2/715
DOI:
10.4021/jocmr965w
PubMed ID:
22719806
PubMed Central ID:
PMC3376878
Type:
Article
ISSN:
1918-3011
Appears in Collections:
Georgia Prevention Center: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorAlvarez, Jessica A.en_US
dc.contributor.authorGower, Barbara A.en_US
dc.contributor.authorCalhoun, David A.en_US
dc.contributor.authorJudd, Suzanne E.en_US
dc.contributor.authorDong, Yanbinen_US
dc.contributor.authorDudenbostel, Tanjaen_US
dc.contributor.authorScholl, Jennien_US
dc.contributor.authorAshraf, Ambika P.en_US
dc.date.accessioned2012-10-26T16:40:52Z-
dc.date.available2012-10-26T16:40:52Z-
dc.date.issued2012-05-15en_US
dc.identifier.citationJ Clin Med Res. 2012 Jun 15; 4(3):197-205en_US
dc.identifier.issn1918-3011en_US
dc.identifier.pmid22719806en_US
dc.identifier.doi10.4021/jocmr965wen_US
dc.identifier.urihttp://hdl.handle.net/10675.2/715-
dc.description.abstractBackground: Vitamin D reportedly influences vascular function, which is worse in African Americans (AAs) relative to European Americans (EAs). It is not clear if ethnic differences in 25(OH)D mediate differences in vascular function. This study examined the relationships of serum 25-hydroxyvitamin D (25(OH)D) with indicators of vascular function among healthy, young AA and EA adults.en_US
dc.description.abstractMethods: This is a cross sectional study involving 23 AAs and 22 EAs. The main outcomes were augmentation index (AIx75), central aortic pressure, pulse wave velocity (PWV), flow-mediated dilation (FMD), and seated and supine blood pressures.en_US
dc.description.abstractResults: Results indicated that 25(OH)D was inversely associated with AIx75, supine systolic blood pressure (SBP), central aortic SBP and central aortic diastolic blood pressure (DBP), independent of age, sex, and percent body fat (standardized β= -0.29 to -0.43, P < 0.05 for all). AAs had greater AIx75 (P = 0.04) and PWV (P = 0.07) and lower FMD (P = 0.02) compared to EA after adjusting for age and percent body fat; further adjustment for 25(OH)D reduced the ethnic differences (P = 0.44, 0.53, and 0.20, respectively).en_US
dc.description.abstractConclusion: The 25(OH)D was associated with vascular function in healthy adults, and lower 25(OH)D among AAs may contribute to their greater arterial stiffness and reduced endothelial function (Clinical trials.gov NCT01041365, NCT01041547).en_US
dc.rightsCopyright 2012, Alvarez et al.en_US
dc.subjectOriginal Articleen_US
dc.titleSerum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Functionen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3376878en_US
dc.contributor.corporatenameGeorgia Institute for Prevention of Human Diseases and Accidents-

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