The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes

Hdl Handle:
http://hdl.handle.net/10675.2/697
Title:
The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes
Authors:
Zhong, Jixin; Rao, Xiaoquan; Xu, Jun-Fa; Yang, Ping; Wang, Cong-Yi
Abstract:
Unlike type 2 diabetes which is caused by the loss of insulin sensitivity, type 1 diabetes (T1D) is manifested by the absolute deficiency of insulin secretion due to the loss of β mass by autoimmune response against β-cell self-antigens. Although significant advancement has been made in understanding the pathoetiology for type 1 diabetes, the exact mechanisms underlying autoimmune-mediated β-cell destruction, however, are yet to be fully addressed. Accumulated evidence demonstrates that endoplasmic reticulum (ER) stress plays an essential role in autoimmune-mediated β-cell destruction. There is also evidence supporting that ER stress regulates the functionality of immune cells relevant to autoimmune progression during T1D development. In this paper, we intend to address the role of ER stress in autoimmune-mediated β-cell destruction during the course of type 1 diabetes. The potential implication of ER stress in modulating autoimmune response will be also discussed. We will further dissect the possible pathways implicated in the induction of ER stress and summarize the potential mechanisms underlying ER stress for mediation of β-cell destruction. A better understanding of the role for ER stress in T1D pathoetiology would have great potential aimed at developing effective therapeutic approaches for the prevention/intervention of this devastating disorder.
Citation:
Exp Diabetes Res. 2012 Feb 14; 2012:238980
Issue Date:
14-Feb-2012
URI:
http://hdl.handle.net/10675.2/697
DOI:
10.1155/2012/238980
PubMed ID:
22454627
PubMed Central ID:
PMC3290823
Type:
Article
ISSN:
1687-5303
Appears in Collections:
Center for Biotechnology and Genomic Medicine: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorZhong, Jixinen_US
dc.contributor.authorRao, Xiaoquanen_US
dc.contributor.authorXu, Jun-Faen_US
dc.contributor.authorYang, Pingen_US
dc.contributor.authorWang, Cong-Yien_US
dc.date.accessioned2012-10-26T16:29:36Z-
dc.date.available2012-10-26T16:29:36Z-
dc.date.issued2012-02-14en_US
dc.identifier.citationExp Diabetes Res. 2012 Feb 14; 2012:238980en_US
dc.identifier.issn1687-5303en_US
dc.identifier.pmid22454627en_US
dc.identifier.doi10.1155/2012/238980en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/697-
dc.description.abstractUnlike type 2 diabetes which is caused by the loss of insulin sensitivity, type 1 diabetes (T1D) is manifested by the absolute deficiency of insulin secretion due to the loss of β mass by autoimmune response against β-cell self-antigens. Although significant advancement has been made in understanding the pathoetiology for type 1 diabetes, the exact mechanisms underlying autoimmune-mediated β-cell destruction, however, are yet to be fully addressed. Accumulated evidence demonstrates that endoplasmic reticulum (ER) stress plays an essential role in autoimmune-mediated β-cell destruction. There is also evidence supporting that ER stress regulates the functionality of immune cells relevant to autoimmune progression during T1D development. In this paper, we intend to address the role of ER stress in autoimmune-mediated β-cell destruction during the course of type 1 diabetes. The potential implication of ER stress in modulating autoimmune response will be also discussed. We will further dissect the possible pathways implicated in the induction of ER stress and summarize the potential mechanisms underlying ER stress for mediation of β-cell destruction. A better understanding of the role for ER stress in T1D pathoetiology would have great potential aimed at developing effective therapeutic approaches for the prevention/intervention of this devastating disorder.en_US
dc.rightsCopyright © 2012 Jixin Zhong et al.en_US
dc.subjectReview Articleen_US
dc.subject.meshCytokinesen_US
dc.subject.meshDiabetes Mellitus, Type 1en_US
dc.subject.meshEndoplasmic Reticulum Stressen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin-Secreting Cellsen_US
dc.titleThe Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetesen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3290823en_US
dc.contributor.corporatenameCenter for Biotechnology and Genomic Medicine-

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