Antimycotic Ciclopirox Olamine in the Diabetic Environment Promotes Angiogenesis and Enhances Wound Healing
Authors
Ko, Sae HeeNauta, Allison
Morrison, Shane D.
Zhou, Hongyan
Zimmermann, Andrew
Gurtner, Geoffrey C.
Ding, Sheng
Longaker, Michael T.
Issue Date
2011-11-18
Metadata
Show full item recordAbstract
Diabetic wounds remain a major medical challenge with often disappointing outcomes despite the best available care. An impaired response to tissue hypoxia and insufficient angiogenesis are major factors responsible for poor healing in diabetic wounds. Here we show that the antimycotic drug ciclopirox olamine (CPX) can induce therapeutic angiogenesis in diabetic wounds. Treatment with CPX in vitro led to upregulation of multiple angiogenic genes and increased availability of HIF-1α. Using an excisional wound splinting model in diabetic mice, we showed that serial topical treatment with CPX enhanced wound healing compared to vehicle control treatment, with significantly accelerated wound closure, increased angiogenesis, and increased dermal cellularity. These findings offer a promising new topical pharmacologic therapy for the treatment of diabetic wounds.Citation
PLoS One. 2011 Nov 18; 6(11):e27844ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0027844
Scopus Count
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