Conjunctive Processing of Locomotor Signals by the Ventral Tegmental Area Neuronal Population

Hdl Handle:
http://hdl.handle.net/10675.2/630
Title:
Conjunctive Processing of Locomotor Signals by the Ventral Tegmental Area Neuronal Population
Authors:
Wang, Dong V.; Tsien, Joe Z.
Abstract:
The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor-related motivational signals that are associated with movement initiation, maintenance and termination.
Citation:
PLoS One. 2011 Jan 27; 6(1):e16528
Issue Date:
27-Jan-2011
URI:
http://hdl.handle.net/10675.2/630
DOI:
10.1371/journal.pone.0016528
PubMed ID:
21304590
PubMed Central ID:
PMC3029369
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Brain & Behavior Discovery Institute: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Dong V.en_US
dc.contributor.authorTsien, Joe Z.en_US
dc.date.accessioned2012-10-26T16:26:55Z-
dc.date.available2012-10-26T16:26:55Z-
dc.date.issued2011-01-27en_US
dc.identifier.citationPLoS One. 2011 Jan 27; 6(1):e16528en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid21304590en_US
dc.identifier.doi10.1371/journal.pone.0016528en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/630-
dc.description.abstractThe ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor-related motivational signals that are associated with movement initiation, maintenance and termination.en_US
dc.rightsWang, Tsien. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectNeuroscienceen_US
dc.subjectCognitive Neuroscienceen_US
dc.subjectCognitionen_US
dc.subjectConsciousnessen_US
dc.subjectNeurophysiologyen_US
dc.subjectCentral Nervous Systemen_US
dc.subjectAnimal Cognitionen_US
dc.subjectBehavioral Neuroscienceen_US
dc.subjectLearning and Memoryen_US
dc.subjectNeuropsychologyen_US
dc.subjectSystems Biologyen_US
dc.titleConjunctive Processing of Locomotor Signals by the Ventral Tegmental Area Neuronal Populationen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3029369en_US
dc.contributor.corporatenameBrain & Behavior Discovery Institute-

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