Hdl Handle:
http://hdl.handle.net/10675.2/622138
Title:
DESIGN AND SYNTHESIS OF HYBRID CONJUGATES AS POTENTIAL ANTI-INFECTIVE AGENTS
Authors:
Littlefield, William E; Wade, Margaret; Makkanal, Tina
Abstract:
Infectious diseases caused by pathogenic microorganisms are major challenges despite all the steps taken to control or cure. New drug development with high efficacy/selectivity for infectious diseases is a point of interest for many researchers. It has reported that tuberculosis is one of the ten major causes of death in the world. Multi-drug resistance (MDR) is another major concern in bacterial and fungal infections. The present study deals with the development of new conjugates of pyrazinoic acid and isoniazid linked via an amino acid. The synthesized conjugates show promising and interesting results against a variety of microbial strains, tuberculous and non-tuberculous mycobacteria. Molecular modeling studies were used for understanding and validation of the experimental data.
Affiliation:
College of Science and Mathematics; Department of Chemistry and Physics
Issue Date:
13-Feb-2019
URI:
http://hdl.handle.net/10675.2/622138
Type:
Poster Presentation
Description:
Presentation given at the 20th Annual Phi Kappa Phi Student Research and Fine Arts Conference
Appears in Collections:
Department of Chemistry and Physics: Student Research and Presentations; Materials Science Research Seminar Series; 20th Annual PKP Student Research and Fine Arts Conference: Posters

Full metadata record

DC FieldValue Language
dc.contributor.authorLittlefield, William Een
dc.contributor.authorWade, Margareten
dc.contributor.authorMakkanal, Tinaen
dc.date.accessioned2019-02-13T20:07:19Z-
dc.date.available2019-02-13T20:07:19Z-
dc.date.issued2019-02-13-
dc.identifier.urihttp://hdl.handle.net/10675.2/622138-
dc.descriptionPresentation given at the 20th Annual Phi Kappa Phi Student Research and Fine Arts Conferenceen
dc.description.abstractInfectious diseases caused by pathogenic microorganisms are major challenges despite all the steps taken to control or cure. New drug development with high efficacy/selectivity for infectious diseases is a point of interest for many researchers. It has reported that tuberculosis is one of the ten major causes of death in the world. Multi-drug resistance (MDR) is another major concern in bacterial and fungal infections. The present study deals with the development of new conjugates of pyrazinoic acid and isoniazid linked via an amino acid. The synthesized conjugates show promising and interesting results against a variety of microbial strains, tuberculous and non-tuberculous mycobacteria. Molecular modeling studies were used for understanding and validation of the experimental data.en
dc.subjectSynthesisen
dc.subjectAnti-infective Agentsen
dc.subjectcomputational studiesen
dc.titleDESIGN AND SYNTHESIS OF HYBRID CONJUGATES AS POTENTIAL ANTI-INFECTIVE AGENTSen
dc.typePoster Presentationen
dc.contributor.departmentCollege of Science and Mathematicsen
dc.contributor.departmentDepartment of Chemistry and Physicsen
cr.funding.sourceAugusta University Scholarly Activity Awarden
dc.contributor.sponsorPanda, Silvaen
dc.contributor.affiliationAugusta Universityen
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