Hdl Handle:
http://hdl.handle.net/10675.2/621760
Title:
Expression and Treatment of Pain-Related Depression of Fixed-Ratio and Progressive-Ratio Food-Maintained Behavior in Rats
Authors:
Baker, Frederick; Frazier, Eric; Marshall, Laura; Sinclair, Sequoia; Thakkar, Parth
Abstract:
Increasingly, preclinical studies on the expression, mechanisms, and treatment of pain have been aimed at improving understanding of pain-related interference with behavior. Positively reinforced operant behaviors are sensitive to depression by physiologically relevant pain stimuli. Most studies using operant conditioning procedures to examine pain-related depression of behavior have used fixed-ratio schedules of reinforcement. The primary dependent variable in these studies is the rate of behavior. In contrast, the primary dependent variable in studies using progressive-ratio schedules of reinforcement is breakpoint. Breakpoint is defined as the total number of reinforcers earned, and is thought to be related to the subject's motivation to obtain the reinforcer. This study examined effects of pain and analgesic manipulations on behavior maintained under fixed-ratio and progressive-ratio schedules of behavior. Intraperitoneal injection of dilute lactic acid was more potent at depressing behavior under the fixed-ratio schedule compared to the progressive-ratio schedule. Ketoprofen was equipotent at blocking pain-related depression of behavior maintained under both schedules. These findings support the validity of operant procedures astools to examine candidateanalgesics for the treatment of pain-related depression of behavior. Moreover, the use of diverse schedules of reinforcement may yield important scientific information on the mechanisms underlying pain-related interference with behavior.
Affiliation:
Department of Psychological Sciences
Issue Date:
12-Feb-2018
URI:
http://hdl.handle.net/10675.2/621760
Submitted date:
26-JAN-2018 01:35PM
Type:
Poster Presentation
Description:
Presentation given at the 19th Annual Phi Kappa Phi Student Research and Fine Arts Conference
Appears in Collections:
19th Annual PKP Student Research and Fine Arts Conference: Posters

Full metadata record

DC FieldValue Language
dc.contributor.authorBaker, Fredericken
dc.contributor.authorFrazier, Ericen
dc.contributor.authorMarshall, Lauraen
dc.contributor.authorSinclair, Sequoiaen
dc.contributor.authorThakkar, Parthen
dc.date.accessioned2018-02-12T17:19:36Z-
dc.date.available2018-02-12T17:19:36Z-
dc.date.issued2018-02-12-
dc.date.submitted26-JAN-2018 01:35PM-
dc.identifier.urihttp://hdl.handle.net/10675.2/621760-
dc.descriptionPresentation given at the 19th Annual Phi Kappa Phi Student Research and Fine Arts Conferenceen
dc.description.abstractIncreasingly, preclinical studies on the expression, mechanisms, and treatment of pain have been aimed at improving understanding of pain-related interference with behavior. Positively reinforced operant behaviors are sensitive to depression by physiologically relevant pain stimuli. Most studies using operant conditioning procedures to examine pain-related depression of behavior have used fixed-ratio schedules of reinforcement. The primary dependent variable in these studies is the rate of behavior. In contrast, the primary dependent variable in studies using progressive-ratio schedules of reinforcement is breakpoint. Breakpoint is defined as the total number of reinforcers earned, and is thought to be related to the subject's motivation to obtain the reinforcer. This study examined effects of pain and analgesic manipulations on behavior maintained under fixed-ratio and progressive-ratio schedules of behavior. Intraperitoneal injection of dilute lactic acid was more potent at depressing behavior under the fixed-ratio schedule compared to the progressive-ratio schedule. Ketoprofen was equipotent at blocking pain-related depression of behavior maintained under both schedules. These findings support the validity of operant procedures astools to examine candidateanalgesics for the treatment of pain-related depression of behavior. Moreover, the use of diverse schedules of reinforcement may yield important scientific information on the mechanisms underlying pain-related interference with behavior.en
dc.titleExpression and Treatment of Pain-Related Depression of Fixed-Ratio and Progressive-Ratio Food-Maintained Behavior in Ratsen
dc.typePoster Presentationen
dc.contributor.departmentDepartment of Psychological Sciencesen
dc.contributor.sponsorMiller, Laurenceen
dc.contributor.sponsorDepartment of Psychological Sciencesen
dc.contributor.affiliationAugusta Universityen
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