The Differential Roles of PI3K P110 Isoforms in Regulating CD4 T Cell Subset Polarization

Hdl Handle:
http://hdl.handle.net/10675.2/621437
Title:
The Differential Roles of PI3K P110 Isoforms in Regulating CD4 T Cell Subset Polarization
Authors:
Webb, Mason James
Abstract:
Class IA phosphatidylinositol-4,5-bisphosphate 3-kinases, or PI3K’s, are one of the earliest bottlenecks for T cell receptor signaling transduction, without which phosphorylated phosphatidylinositides cannot be generated and the T cell activation cascade becomes impaired. Of the catalytic class IA PI3K subunits, there are three isoforms designated as p110α, p110β, and p110δ. The Khleif laboratory has discovered that these catalytic subunits display unique roles in T regulatory cells and non-polarized activated CD4+ T cells. This thesis aims to determine what differential control these p110 isoforms have upon distinct polarized CD4+ T cell subsets.
Affiliation:
Department of Biochemistry and Molecular Biology
Issue Date:
12-May-2017
URI:
http://hdl.handle.net/10675.2/621437
Type:
dissertation
Appears in Collections:
Department of Biochemistry and Molecular Biology Theses and Dissertations; Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorWebb, Mason Jamesen
dc.date.accessioned2017-05-12T16:15:43Z-
dc.date.available2017-05-12T16:15:43Z-
dc.date.issued2017-05-12-
dc.identifier.urihttp://hdl.handle.net/10675.2/621437-
dc.description.abstractClass IA phosphatidylinositol-4,5-bisphosphate 3-kinases, or PI3K’s, are one of the earliest bottlenecks for T cell receptor signaling transduction, without which phosphorylated phosphatidylinositides cannot be generated and the T cell activation cascade becomes impaired. Of the catalytic class IA PI3K subunits, there are three isoforms designated as p110α, p110β, and p110δ. The Khleif laboratory has discovered that these catalytic subunits display unique roles in T regulatory cells and non-polarized activated CD4+ T cells. This thesis aims to determine what differential control these p110 isoforms have upon distinct polarized CD4+ T cell subsets.en
dc.subjectcellular biologyen
dc.subjectImmunologyen
dc.subjectOncologyen
dc.titleThe Differential Roles of PI3K P110 Isoforms in Regulating CD4 T Cell Subset Polarization-
dc.typedissertationen
dc.contributor.departmentDepartment of Biochemistry and Molecular Biologyen
dc.language.rfc3066en-
dc.date.updated2017-05-12T16:15:43Z-
dc.description.advisorKhleif, Samir N.en
dc.description.committeeBollag, Wendy; He, Yukai; Manicassamy, Santhakumar; Rodrigeuz, Pauloen
dc.description.degreeDoctor of Philosophy with a Major in Biochemistry & Cancer Biologyen
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