Hdl Handle:
http://hdl.handle.net/10675.2/615
Title:
Operant Sensation Seeking Requires Metabotropic Glutamate Receptor 5 (mGluR5)
Authors:
Olsen, Christopher M.; Childs, Daniel S.; Stanwood, Gregg D.; Winder, Danny G.
Abstract:
Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO), heterozygous (Het), and wildtype (WT) mice to determine if mGluR5 modulates operant sensation seeking (OSS), an operant task that uses varied sensory stimuli as a reinforcer. We found that mGluR5 KO mice had significantly reduced OSS responding relative to WT mice, while Het mice displayed a paradoxical increase in OSS responding. Neither KO nor Het mice exhibited altered operant responding for food as a reinforcer. Further, we assessed mGluR5 KO, Het and WT mice across a battery of cocaine locomotor, place preference and anxiety related tests. Although KO mice showed expected differences in some locomotor and anxiety measures, Het mice either exhibited no phenotype or an intermediate one. In total, these data demonstrate a key role for mGluR5 in OSS, indicating an important role for this receptor in reinforcement-based behavior.
Editors:
Tsien, Joe Z.
Citation:
PLoS One. 2010 Nov 30; 5(11):e15085
Issue Date:
30-Nov-2010
URI:
http://hdl.handle.net/10675.2/615
DOI:
10.1371/journal.pone.0015085
PubMed ID:
21152045
PubMed Central ID:
PMC2994905
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Department of Neurology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorOlsen, Christopher M.en_US
dc.contributor.authorChilds, Daniel S.en_US
dc.contributor.authorStanwood, Gregg D.en_US
dc.contributor.authorWinder, Danny G.en_US
dc.contributor.editorTsien, Joe Z.-
dc.date.accessioned2012-10-26T16:26:53Z-
dc.date.available2012-10-26T16:26:53Z-
dc.date.issued2010-11-30en_US
dc.identifier.citationPLoS One. 2010 Nov 30; 5(11):e15085en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid21152045en_US
dc.identifier.doi10.1371/journal.pone.0015085en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/615-
dc.description.abstractPharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO), heterozygous (Het), and wildtype (WT) mice to determine if mGluR5 modulates operant sensation seeking (OSS), an operant task that uses varied sensory stimuli as a reinforcer. We found that mGluR5 KO mice had significantly reduced OSS responding relative to WT mice, while Het mice displayed a paradoxical increase in OSS responding. Neither KO nor Het mice exhibited altered operant responding for food as a reinforcer. Further, we assessed mGluR5 KO, Het and WT mice across a battery of cocaine locomotor, place preference and anxiety related tests. Although KO mice showed expected differences in some locomotor and anxiety measures, Het mice either exhibited no phenotype or an intermediate one. In total, these data demonstrate a key role for mGluR5 in OSS, indicating an important role for this receptor in reinforcement-based behavior.en_US
dc.rightsOlsen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectBiochemistryen_US
dc.subjectNeurochemistryen_US
dc.subjectNeurochemicalsen_US
dc.subjectGlutamateen_US
dc.subjectGeneticsen_US
dc.subjectAnimal Geneticsen_US
dc.subjectGene Expressionen_US
dc.subjectGene Functionen_US
dc.subjectModel Organismsen_US
dc.subjectAnimal Modelsen_US
dc.subjectMouseen_US
dc.subjectNeuroscienceen_US
dc.subjectCognitive Neuroscienceen_US
dc.subjectInhibitionsen_US
dc.subjectMolecular Neuroscienceen_US
dc.subjectSignaling Pathwaysen_US
dc.subjectNeurochemistryen_US
dc.subjectNeurochemicalsen_US
dc.subjectGlutamateen_US
dc.subjectBehavioral Neuroscienceen_US
dc.subjectLearning and Memoryen_US
dc.subjectNeurotransmittersen_US
dc.subjectMedicineen_US
dc.subjectNeurologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCocaineen_US
dc.subject.meshConditioning, Operanten_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshMaleen_US
dc.subject.meshMaze Learningen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshMotor Activityen_US
dc.subject.meshReceptors, Metabotropic Glutamateen_US
dc.subject.meshReinforcement (Psychology)en_US
dc.subject.meshSelf Administrationen_US
dc.subject.meshSensationen_US
dc.subject.meshVasoconstrictor Agentsen_US
dc.titleOperant Sensation Seeking Requires Metabotropic Glutamate Receptor 5 (mGluR5)en_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2994905en_US
dc.contributor.corporatenameDepartment of Neurology-
dc.contributor.corporatenameCollege of Graduate Studies-

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