Behavioral Consequences of NMDA Antagonist-Induced Neuroapoptosis in the Infant Mouse Brain

Hdl Handle:
http://hdl.handle.net/10675.2/590
Title:
Behavioral Consequences of NMDA Antagonist-Induced Neuroapoptosis in the Infant Mouse Brain
Authors:
Yuede, Carla M.; Wozniak, David F.; Creeley, Catherine E.; Taylor, George T.; Olney, John W.; Farber, Nuri B.
Abstract:
Background: Exposure to NMDA glutamate antagonists during the brain growth spurt period causes widespread neuroapoptosis in the rodent brain. This period in rodents occurs during the first two weeks after birth, and corresponds to the third trimester of pregnancy and several years after birth in humans. The developing human brain may be exposed to NMDA antagonists through drug-abusing mothers or through anesthesia.; Methodology/Principal Findings: We evaluated the long-term neurobehavioral effects of mice exposed to a single dose of the NMDA antagonist, phencyclidine (PCP), or saline, on postnatal day 2 (P2) or P7, or on both P2 and P7. PCP treatment on P2 + P7 caused more severe cognitive impairments than either single treatment. Histological examination of acute neuroapoptosis resulting from exposure to PCP indicated that the regional pattern of degeneration induced by PCP in P2 pups was different from that in P7 pups. The extent of damage when evaluated quantitatively on P7 was greater for pups previously treated on P2 compared to pups treated only on P7.; Conclusions: These findings signify that PCP induces different patterns of neuroapoptosis depending on the developmental age at the time of exposure, and that exposure at two separate developmental ages causes more severe neuropathological and neurobehavioral consequences than a single treatment.
Editors:
Mei, Lin
Citation:
PLoS One. 2010 Jun 29; 5(6):e11374
Issue Date:
29-Jun-2010
URI:
http://hdl.handle.net/10675.2/590
DOI:
10.1371/journal.pone.0011374
PubMed ID:
20613880
PubMed Central ID:
PMC2894063
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Department of Neurology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorYuede, Carla M.en_US
dc.contributor.authorWozniak, David F.en_US
dc.contributor.authorCreeley, Catherine E.en_US
dc.contributor.authorTaylor, George T.en_US
dc.contributor.authorOlney, John W.en_US
dc.contributor.authorFarber, Nuri B.en_US
dc.contributor.editorMei, Lin-
dc.date.accessioned2012-10-26T16:26:48Z-
dc.date.available2012-10-26T16:26:48Z-
dc.date.issued2010-06-29en_US
dc.identifier.citationPLoS One. 2010 Jun 29; 5(6):e11374en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid20613880en_US
dc.identifier.doi10.1371/journal.pone.0011374en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/590-
dc.description.abstractBackground: Exposure to NMDA glutamate antagonists during the brain growth spurt period causes widespread neuroapoptosis in the rodent brain. This period in rodents occurs during the first two weeks after birth, and corresponds to the third trimester of pregnancy and several years after birth in humans. The developing human brain may be exposed to NMDA antagonists through drug-abusing mothers or through anesthesia.en_US
dc.description.abstractMethodology/Principal Findings: We evaluated the long-term neurobehavioral effects of mice exposed to a single dose of the NMDA antagonist, phencyclidine (PCP), or saline, on postnatal day 2 (P2) or P7, or on both P2 and P7. PCP treatment on P2 + P7 caused more severe cognitive impairments than either single treatment. Histological examination of acute neuroapoptosis resulting from exposure to PCP indicated that the regional pattern of degeneration induced by PCP in P2 pups was different from that in P7 pups. The extent of damage when evaluated quantitatively on P7 was greater for pups previously treated on P2 compared to pups treated only on P7.en_US
dc.description.abstractConclusions: These findings signify that PCP induces different patterns of neuroapoptosis depending on the developmental age at the time of exposure, and that exposure at two separate developmental ages causes more severe neuropathological and neurobehavioral consequences than a single treatment.en_US
dc.rightsYuede et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectNeuroscience/Behavioral Neuroscienceen_US
dc.subjectNeuroscience/Neurodevelopmenten_US
dc.subjectNeurological Disorders/Neuropharmacologyen_US
dc.subjectNeurological Disorders/Neuropsychiatric Disordersen_US
dc.subjectNeuroscience/Experimental Psychologyen_US
dc.titleBehavioral Consequences of NMDA Antagonist-Induced Neuroapoptosis in the Infant Mouse Brainen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2894063en_US
dc.contributor.corporatenameDepartment of Neurology-
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