Effects of monoamine uptake inhibitors in an assay of pain-related depression of behavior in male mice

Hdl Handle:
http://hdl.handle.net/10675.2/582991
Title:
Effects of monoamine uptake inhibitors in an assay of pain-related depression of behavior in male mice
Authors:
Alexander, Khadijah
Abstract:
Consequences of pain include stimulation of some behaviors (e.g. vocalization, reflexive withdrawal from stimuli), and depression of others (e.g. exercise, and work). Pain-related decreases in behavior are among the primary diagnostic and treatment concerns for physicians, but preclinical research has often ignored this important endpoint. This discrepancy between basic research and clinical application may be one obstacle to the development of new pain treatments. In the present study, we modeled pain-related depression of behavior by examining nesting behavior in male ICR mice. Nest building is an innate mouse behavior that is sensitive to depression by a pain stimulus, and pain-related depression of nesting is blocked by the clinically effective nonsteroidal anti-inflammatory drug (NSAID) ketoprofen. This project examines effects of monoamine uptake inhibitors with varying selectivity for serotonin (5HT), norepinephrine (NE) and dopamine (DA) on pain-related depression of nesting. Citalopram (5HT-selective), nisoxetine (NE-selective), milnacipran (mixed action, 5HT/NE-selective), and bupropion (DA-selective) were evaluated for their ability to block pain-related depression of nesting. Results show that the monoamine uptake inhibitors lacking significant dopamine had no effect on pain-depressed nesting. This finding is consistent with previous work suggesting that dopamine may be a key neurochemical target in the treatment of pain-related depression of behavior. Begin Time: 09:28 End Time: 28:00
Affiliation:
College of Science and Mathematics
Issue Date:
9-Oct-2015
URI:
http://hdl.handle.net/10675.2/582991
Additional Links:
https://lecture.gru.edu/ess/echo/presentation/f163fe4f-f659-40d7-83e8-ac5c050abc8c?ec=true
Type:
Presentation
Language:
en_US
Description:
Presentation given at the CURS Brown Bag Seminar Series on October 9, 2015
Series/Report no.:
Fall; 2015
Sponsors:
Center for Undergraduate Research and Scholarship; College of Science and Mathematics; Department of Psychological Sciences
Appears in Collections:
CURS Brown Bag Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorAlexander, Khadijahen
dc.date.accessioned2015-11-30T20:44:11Zen
dc.date.available2015-11-30T20:44:11Zen
dc.date.issued2015-10-09en
dc.identifier.urihttp://hdl.handle.net/10675.2/582991en
dc.descriptionPresentation given at the CURS Brown Bag Seminar Series on October 9, 2015en
dc.description.abstractConsequences of pain include stimulation of some behaviors (e.g. vocalization, reflexive withdrawal from stimuli), and depression of others (e.g. exercise, and work). Pain-related decreases in behavior are among the primary diagnostic and treatment concerns for physicians, but preclinical research has often ignored this important endpoint. This discrepancy between basic research and clinical application may be one obstacle to the development of new pain treatments. In the present study, we modeled pain-related depression of behavior by examining nesting behavior in male ICR mice. Nest building is an innate mouse behavior that is sensitive to depression by a pain stimulus, and pain-related depression of nesting is blocked by the clinically effective nonsteroidal anti-inflammatory drug (NSAID) ketoprofen. This project examines effects of monoamine uptake inhibitors with varying selectivity for serotonin (5HT), norepinephrine (NE) and dopamine (DA) on pain-related depression of nesting. Citalopram (5HT-selective), nisoxetine (NE-selective), milnacipran (mixed action, 5HT/NE-selective), and bupropion (DA-selective) were evaluated for their ability to block pain-related depression of nesting. Results show that the monoamine uptake inhibitors lacking significant dopamine had no effect on pain-depressed nesting. This finding is consistent with previous work suggesting that dopamine may be a key neurochemical target in the treatment of pain-related depression of behavior. Begin Time: 09:28 End Time: 28:00en
dc.description.sponsorshipCenter for Undergraduate Research and Scholarship; College of Science and Mathematics; Department of Psychological Sciencesen
dc.language.isoen_USen
dc.relation.ispartofseriesFallen
dc.relation.ispartofseries2015en
dc.relation.urlhttps://lecture.gru.edu/ess/echo/presentation/f163fe4f-f659-40d7-83e8-ac5c050abc8c?ec=trueen
dc.subjectMiceen
dc.subjectNesting Behavioren
dc.subjectNorepinephrineen
dc.subjectKetoprofenen
dc.subjectDopamineen
dc.titleEffects of monoamine uptake inhibitors in an assay of pain-related depression of behavior in male miceen_US
dc.typePresentationen
dc.contributor.departmentCollege of Science and Mathematicsen
dc.contributor.mentorMIller, Laurenceen
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