Natural Spike Trains Trigger Short- and Long-Lasting Dynamics at Hippocampal Mossy Fiber Synapses in Rodents

Hdl Handle:
http://hdl.handle.net/10675.2/581
Title:
Natural Spike Trains Trigger Short- and Long-Lasting Dynamics at Hippocampal Mossy Fiber Synapses in Rodents
Authors:
Gundlfinger, Anja; Breustedt, Jorg; Sullivan, David; Schmitz, Dietmar
Abstract:
Background: Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular.; Methodology/Principal Findings: Using extracellular and whole-cell electrophysiological recordings, we have here studied the synaptic responses at hippocampal mossy fiber synapses in vitro to stimulus patterns obtained from in vivo recordings of place cell firing of dentate gyrus granule cells in behaving rodents. We find that synaptic strength is strongly modulated on short- and long-lasting time scales during the presentation of the natural stimulus trains.; Conclusions/Significance: We conclude that dynamic short- and long-term synaptic plasticity at the hippocampal mossy fiber synapse plays a prominent role in normal synaptic function.
Editors:
Tsien, Joe Z.
Citation:
PLoS One. 2010 Apr 1; 5(4):e9961
Issue Date:
1-Apr-2010
URI:
http://hdl.handle.net/10675.2/581
DOI:
10.1371/journal.pone.0009961
PubMed ID:
20376354
PubMed Central ID:
PMC2848597
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Department of Neurology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorGundlfinger, Anjaen_US
dc.contributor.authorBreustedt, Jorgen_US
dc.contributor.authorSullivan, Daviden_US
dc.contributor.authorSchmitz, Dietmaren_US
dc.contributor.editorTsien, Joe Z.-
dc.date.accessioned2012-10-26T16:26:47Z-
dc.date.available2012-10-26T16:26:47Z-
dc.date.issued2010-04-1en_US
dc.identifier.citationPLoS One. 2010 Apr 1; 5(4):e9961en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid20376354en_US
dc.identifier.doi10.1371/journal.pone.0009961en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/581-
dc.description.abstractBackground: Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular.en_US
dc.description.abstractMethodology/Principal Findings: Using extracellular and whole-cell electrophysiological recordings, we have here studied the synaptic responses at hippocampal mossy fiber synapses in vitro to stimulus patterns obtained from in vivo recordings of place cell firing of dentate gyrus granule cells in behaving rodents. We find that synaptic strength is strongly modulated on short- and long-lasting time scales during the presentation of the natural stimulus trains.en_US
dc.description.abstractConclusions/Significance: We conclude that dynamic short- and long-term synaptic plasticity at the hippocampal mossy fiber synapse plays a prominent role in normal synaptic function.en_US
dc.rightsGundlfinger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectNeuroscienceen_US
dc.subjectNeuroscience/Neuronal and Glial Cell Biologyen_US
dc.subjectNeuroscience/Neuronal Signaling Mechanismsen_US
dc.titleNatural Spike Trains Trigger Short- and Long-Lasting Dynamics at Hippocampal Mossy Fiber Synapses in Rodentsen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2848597en_US
dc.contributor.corporatenameDepartment of Neurology-
dc.contributor.corporatenameCollege of Graduate Studies-

Related articles on PubMed

All Items in Scholarly Commons are protected by copyright, with all rights reserved, unless otherwise indicated.