Regulation of Embryonic Stem Cell Pluripotency and Differentiation by Notch Signaling

Hdl Handle:
http://hdl.handle.net/10675.2/552715
Title:
Regulation of Embryonic Stem Cell Pluripotency and Differentiation by Notch Signaling
Authors:
Noggle, Scott A
Abstract:
(First Paragraph) Mammalian development prior to implantation is primarily involved with establishing the support tissues needed for interaction with the mother’s uterine tissue and blood stream as the uterine tissue prepares to receive the embryo. Development of the embryo proceeds slowly while initiating differentiation of the first cell lineages, trophectoderm and the primitive endoderm, that are necessary for interactions with the mother’s uterine tissue. In mice, development from fertilization to the initiation of implantation of the blastocyst into the uterine wall takes about four and a half days (Fig. 1) whereas this period in human development requires about 7 days. This is in contrast to the much-accelerated development, for example, of amphibian species that produce embryos that develop in isolation of maternal support after fertilization.
Affiliation:
Institute of Molecular Medicine and Genetics
Issue Date:
May-2004
URI:
http://hdl.handle.net/10675.2/552715
Additional Links:
http://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/305097615?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations; Institute of Molecular Medicine and Genetics Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorNoggle, Scott Aen
dc.date.accessioned2015-05-14T02:00:27Zen
dc.date.available2015-05-14T02:00:27Zen
dc.date.issued2004-05en
dc.identifier.urihttp://hdl.handle.net/10675.2/552715-
dc.description.abstract(First Paragraph) Mammalian development prior to implantation is primarily involved with establishing the support tissues needed for interaction with the mother’s uterine tissue and blood stream as the uterine tissue prepares to receive the embryo. Development of the embryo proceeds slowly while initiating differentiation of the first cell lineages, trophectoderm and the primitive endoderm, that are necessary for interactions with the mother’s uterine tissue. In mice, development from fertilization to the initiation of implantation of the blastocyst into the uterine wall takes about four and a half days (Fig. 1) whereas this period in human development requires about 7 days. This is in contrast to the much-accelerated development, for example, of amphibian species that produce embryos that develop in isolation of maternal support after fertilization.en
dc.relation.urlhttp://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/305097615?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectAnimalsen
dc.subjectBlastocysten
dc.subjectCell Lineageen
dc.subjectEmbryo Implantationen
dc.subjectEndodermen
dc.subjectFicusen
dc.subjectMammalsen
dc.subjectUterusen
dc.titleRegulation of Embryonic Stem Cell Pluripotency and Differentiation by Notch Signalingen
dc.typeDissertationen
dc.contributor.departmentInstitute of Molecular Medicine and Geneticsen
dc.description.advisorCondie, Brianen
dc.description.committeeNot Listeden
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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