Hdl Handle:
http://hdl.handle.net/10675.2/539
Title:
BENZPYRENE HYDROXYLASE ACTIVITY IN ISOLATED PARENCHYMAL AND NONPARENCHYMAL CELLS OF RAT LIVER
Authors:
Cantrell, Elroy; Bresnick, Edward
Abstract:
Previous studies have implicated the reticuloendothelial cells of the liver in certain aspects of steroid metabolism. The similarity in the metabolism of steroids and polycyclic hydrocarbons suggested that the nonparenchymal cells possibly play a role in these areas . The present study presents evidence that at least one of the microsomal NADPH-requirig enzymes, benzpyrene hydroxylase, is present in nonparenchymal cells and, furthermore, is "inducible ." In adult rats treated with 3-methylcholanthrene or ß-naphthoflavone, the nonparenchymal cells exhibited increases in benzpyrene hydroxylase activity of 17-fold and five-fold, respectively . Treatment with phenobarbital resulted in only a slight increase in enzyme activity . Enzyme activity in parenchymal cells under similar conditions was increased sixfold and fivefold by 3-methylcholanthrene and ß-naphthoflavone, respectively, but not by phenobarbital.
Citation:
J Cell Biol. 1972 Feb 1; 52(2):316-321
Issue Date:
1-Feb-1972
URI:
http://hdl.handle.net/10675.2/539
PubMed ID:
4333451
PubMed Central ID:
PMC2108624
Type:
Article
ISSN:
1540-8140
Appears in Collections:
Department of Cellular Biology and Anatomy: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorCantrell, Elroyen_US
dc.contributor.authorBresnick, Edwarden_US
dc.date.accessioned2012-10-26T16:26:35Z-
dc.date.available2012-10-26T16:26:35Z-
dc.date.issued1972-02-1en_US
dc.identifier.citationJ Cell Biol. 1972 Feb 1; 52(2):316-321en_US
dc.identifier.issn1540-8140en_US
dc.identifier.pmid4333451en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/539-
dc.description.abstractPrevious studies have implicated the reticuloendothelial cells of the liver in certain aspects of steroid metabolism. The similarity in the metabolism of steroids and polycyclic hydrocarbons suggested that the nonparenchymal cells possibly play a role in these areas . The present study presents evidence that at least one of the microsomal NADPH-requirig enzymes, benzpyrene hydroxylase, is present in nonparenchymal cells and, furthermore, is "inducible ." In adult rats treated with 3-methylcholanthrene or ß-naphthoflavone, the nonparenchymal cells exhibited increases in benzpyrene hydroxylase activity of 17-fold and five-fold, respectively . Treatment with phenobarbital resulted in only a slight increase in enzyme activity . Enzyme activity in parenchymal cells under similar conditions was increased sixfold and fivefold by 3-methylcholanthrene and ß-naphthoflavone, respectively, but not by phenobarbital.en_US
dc.rightsCopyright © 1972 by The Rockefeller University Pressen_US
dc.titleBENZPYRENE HYDROXYLASE ACTIVITY IN ISOLATED PARENCHYMAL AND NONPARENCHYMAL CELLS OF RAT LIVERen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2108624en_US
dc.contributor.corporatenameDepartment of Cellular Biology and Anatomy-
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