MCG Critically Appraised Topics
A Critically Appraised Topic (CAT) is a short summary of the best available evidence, created to answer a specific clinical question.
Recent Submissions
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Assessing the Validity of Vitamin D Supplementation in Patients with Symptomatic Knee OsteoarthritisIn an older adult population, does supplementation of 25-hydroxyvitamin D for patients with symptomatic knee osteoarthritis with low serum vitamin D alleviate symptoms of the disease?
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Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment optionsDoes treatment with sofosbuvir for Hepatitis C genotype 2 or 3 patients for whom peginterferon and ribavirin treatment was not an option lead to a sustained virologic response at 12 week weeks after therapy?
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Effectiveness of Combination Therapy with Sofosbuvir for the Treatment of Chronic HCV Genotype 1, 2, 4, 5, and 6.Is combination therapy with Sofosbuvir an effective treatment for chronic Hepatitis C genotypes 1,2,4, 5, and 6 when compared to placebo?
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The Efficacy of Moxifloxacin in the Treatment of Multidrug-resistant TuberculosisWhat is the efficacy of the use of moxifloxacin in the treatment of multidrug-resistant mycobacterium tuberculosis (MDR-TB) compared to other MDR-TB therapies?
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Diagnostic accuracy of faecal calprotectin estimation in prediction of abnormal small bowel radiologyDoes a test measuring fecal calprotectin levels rather than erythrocyte sedimentation rate and C-reactive protein help to better confirm (or rule out) a diagnosis of irritable bowel syndrome?
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The timing of CAGE screening results and their likelihood to increase physician-patient discussion of alcoholism and subsequent alcohol useWill providing physicians with screening results from CAGE questionnaire, preliminary assessment results, and specific individualized recommendations concerning patients identified as current “hazardous drinkers” before the seeing the patient increase the likelihood of a patient physician discussion of alcoholism and affect their subsequent alcohol use?
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The Accuracy of Clinical Examination in the Diagnosis of Rectal IntussusceptionWill physical examination or defecography result in better detection of rectal intussusception in patients with constipation?
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An examination of the "gold standard" diagnosis of major depression in aged-care settingsIn older people, who are known to underreport depressive symptomatology, will the prevalence of diagnosed major depressive disorder (MDD) change if an informant interview is added to the “gold standard” individual clinical interview?
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HIV screening performance using third generation enzyme linked immunosorbent assay compared to fourth-generation electrochemiluminescence immunoassayShould fourth-generation electrochemiluminescence immunoassay (ChIA) be used over third-generation enzyme linked immunosorbent assay (EIA) for HIV screening patients in multiethnic region of China?
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Incidence of osteoporosis in men diagnosed with prostate cancerWhat is the incidence of osteoporosis in men with advanced prostate cancer and how does this diagnosis effect treatment for the cancer?
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The effect of screening sonography on the positive rate of enemas for intussusceptionFor newborns and young infants with suspected intussusception, are ultrasounds a better screening option than enemas?
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The effectiveness of serum cross-linked N-telopeptide (NTx) and amnioterminal procollagen extension propeptide (PINP) measurements for identifying osteoporosis in elderly womenCan screening for serum cross-linked N-telopeptide (NTx) and aminoterminal procollagen extension propeptide (PINP) identify decreased bone mineral density in elderly women effectively when compared with whole-body femoral neck and lumbar spine dual emission X-ray absorptiometry?
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Using digital mammography with tomosynthesis to detect breast cancerDoes the use of tomosynthesis in combination with digital mammography result in better screening and detection rate for breast cancer?
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Thoracic Staging in Lung Cancer: Prospective Comparison of 18F-FDG PET/MR Imaging and 18F-FDG PET/CTWill 18F-FDG PET/MR Imaging provide a higher diagnostic value compared to 18F-FDG PET/CT for thoracic T and N staging of non-small cell lung cancer (NSCLC)?
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Open-magnet MR defaecography compared with evacuation proctography in the diagnosis and management of patients with rectal intussusceptionFor patients with rectal intussusception, will the use of open-magnet magnetic resonance (MR) defaecography in addition to evacuation proctography (EP) result in better diagnosis and management?
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The effectiveness of the Memory Orientation Screening Test (MOST) for potential dementia patientsWhat is a rapid and accurate screening test to diagnose dementia?