The Role of Trigger Factor in Campylobacter Jejuni Pathogenesis

Hdl Handle:
http://hdl.handle.net/10675.2/317548
Title:
The Role of Trigger Factor in Campylobacter Jejuni Pathogenesis
Authors:
Agee, Willie Andrew III ( 0000-0002-1881-4737 )
Abstract:
The first description of Campylobacter was by Theodor Esherich in 1886 when he published several articles noting a spiral bacterium in the colons of children who died of what Esherich called “cholera infantum”(10, 99) Esherich attempted to culture these spiral bacteria but was unable to do so (10, 99). He also found the bacteria in the stool of a significant number of infants suffering from gastrointestinal illness but he believed they played no role in the disease (10, 99). Unfortunately, because Esherich’s observations were published in German, his contribution in recognizing Campylobacter was not fully recognized until 1985 (10). Campylobacter was also recognized as a veterinary disease agent that causes abortion in ewes, sterility in cows and dysentery in calves (10). In 1909 veterinarians McFadyean and Stockman isolated a spiral bacterium from aborted sheep fetuses (10, 75). Ten years later Smith investigated cases of bovine abortion and isolated a spiral shaped bacterium (10, 98). He concluded that it was the same bacterium isolated by McFadyean and Stockman and proposed the name Vibrio fetus (10, 98). In 1949 Stegenga et al. discovered that V. fetus venerealis caused sterility in cows, and Florent showed there were two subspecies of V. fetus based on their biochemical and pathogenic characteristics (10, 23, 102). These subspecies were named V. fetus venerealis and V. fetus intestinalis based on causing sterility or dysentery respectively (10).
Affiliation:
Department of Medicine
Issue Date:
Apr-2010
URI:
http://hdl.handle.net/10675.2/317548
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/288239806?accountid=12365
Type:
Thesis
Language:
en_US
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorAgee, Willie Andrew IIIen
dc.date.accessioned2014-05-28T00:13:53Z-
dc.date.available2014-05-28T00:13:53Z-
dc.date.issued2010-04-
dc.identifier.urihttp://hdl.handle.net/10675.2/317548-
dc.description.abstractThe first description of Campylobacter was by Theodor Esherich in 1886 when he published several articles noting a spiral bacterium in the colons of children who died of what Esherich called “cholera infantum”(10, 99) Esherich attempted to culture these spiral bacteria but was unable to do so (10, 99). He also found the bacteria in the stool of a significant number of infants suffering from gastrointestinal illness but he believed they played no role in the disease (10, 99). Unfortunately, because Esherich’s observations were published in German, his contribution in recognizing Campylobacter was not fully recognized until 1985 (10). Campylobacter was also recognized as a veterinary disease agent that causes abortion in ewes, sterility in cows and dysentery in calves (10). In 1909 veterinarians McFadyean and Stockman isolated a spiral bacterium from aborted sheep fetuses (10, 75). Ten years later Smith investigated cases of bovine abortion and isolated a spiral shaped bacterium (10, 98). He concluded that it was the same bacterium isolated by McFadyean and Stockman and proposed the name Vibrio fetus (10, 98). In 1949 Stegenga et al. discovered that V. fetus venerealis caused sterility in cows, and Florent showed there were two subspecies of V. fetus based on their biochemical and pathogenic characteristics (10, 23, 102). These subspecies were named V. fetus venerealis and V. fetus intestinalis based on causing sterility or dysentery respectively (10).en
dc.language.isoen_USen
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/288239806?accountid=12365en
dc.rightsAccess restricted to authorized Georgia Regents users only.en
dc.rightsAn error occurred on the license name.*
dc.rights.uriAn error occurred getting the license - uri.*
dc.subjectCampylobacter jejunien
dc.subjectE. colien
dc.subjectListeria monocytogenesen
dc.subjectStreptococcus mutansen
dc.subjectStreptococcus pyogenesen
dc.subjectPsychrobacter frigidicolaen
dc.titleThe Role of Trigger Factor in Campylobacter Jejuni Pathogenesisen
dc.typeThesisen
dc.contributor.departmentDepartment of Medicineen
dc.contributor.corporatenameGeorgia Regents Universityen
dc.description.advisorTrent, Stephen M.-
dc.description.committeeTrent, Stephen M.; Caughman, Gretchen; Atherton, Sally; Volkmann, Keith-
dc.description.degreeDoctor of Philosophy (Ph.D.)-
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