Hdl Handle:
http://hdl.handle.net/10675.2/154
Title:
Neural population-level memory traces in the mouse hippocampus.
Authors:
Chen, Guifen; Wang, Lei Phillip; Tsien, Joe Z.
Abstract:
One of the fundamental goals in neurosciences is to elucidate the formation and retrieval of brain's associative memory traces in real-time. Here, we describe real-time neural ensemble transient dynamics in the mouse hippocampal CA1 region and demonstrate their relationships with behavioral performances during both learning and recall. We employed the classic trace fear conditioning paradigm involving a neutral tone followed by a mild foot-shock 20 seconds later. Our large-scale recording and decoding methods revealed that conditioned tone responses and tone-shock association patterns were not present in CA1 during the first pairing, but emerged quickly after multiple pairings. These encoding patterns showed increased immediate-replay, correlating tightly with increased immediate-freezing during learning. Moreover, during contextual recall, these patterns reappeared in tandem six-to-fourteen times per minute, again correlating tightly with behavioral recall. Upon traced tone recall, while various fear memories were retrieved, the shock traces exhibited a unique recall-peak around the 20-second trace interval, further signifying the memory of time for the expected shock. Therefore, our study has revealed various real-time associative memory traces during learning and recall in CA1, and demonstrates that real-time memory traces can be decoded on a moment-to-moment basis over any single trial.
Citation:
PLoS One. 2009 Dec 16; 4(12):e8256
Issue Date:
17-Dec-2009
URI:
http://hdl.handle.net/10675.2/154
DOI:
10.1371/journal.pone.0008256
PubMed ID:
20016843
PubMed Central ID:
PMC2788416
Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
ISSN:
1932-6203
Appears in Collections:
Brain & Behavior Discovery Institute: Faculty Research and Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorChen, Guifenen_US
dc.contributor.authorWang, Lei Phillipen_US
dc.contributor.authorTsien, Joe Z.en_US
dc.date.accessioned2010-09-24T22:09:18Z-
dc.date.available2010-09-24T22:09:18Z-
dc.date.issued2009-12-17en_US
dc.identifier.citationPLoS One. 2009 Dec 16; 4(12):e8256en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid20016843en_US
dc.identifier.doi10.1371/journal.pone.0008256en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/154-
dc.description.abstractOne of the fundamental goals in neurosciences is to elucidate the formation and retrieval of brain's associative memory traces in real-time. Here, we describe real-time neural ensemble transient dynamics in the mouse hippocampal CA1 region and demonstrate their relationships with behavioral performances during both learning and recall. We employed the classic trace fear conditioning paradigm involving a neutral tone followed by a mild foot-shock 20 seconds later. Our large-scale recording and decoding methods revealed that conditioned tone responses and tone-shock association patterns were not present in CA1 during the first pairing, but emerged quickly after multiple pairings. These encoding patterns showed increased immediate-replay, correlating tightly with increased immediate-freezing during learning. Moreover, during contextual recall, these patterns reappeared in tandem six-to-fourteen times per minute, again correlating tightly with behavioral recall. Upon traced tone recall, while various fear memories were retrieved, the shock traces exhibited a unique recall-peak around the 20-second trace interval, further signifying the memory of time for the expected shock. Therefore, our study has revealed various real-time associative memory traces during learning and recall in CA1, and demonstrates that real-time memory traces can be decoded on a moment-to-moment basis over any single trial.en_US
dc.rightsThe PMC Open Access Subset is a relatively small part of the total collection of articles in PMC. Articles in the PMC Open Access Subset are still protected by copyright, but are made available under a Creative Commons or similar license that generally allows more liberal redistribution and reuse than a traditional copyrighted work. Please refer to the license statement in each article for specific terms of use. The license terms are not identical for all articles in this subset.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshConditioning (Psychology)en_US
dc.subject.meshFearen_US
dc.subject.meshHippocampus / physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMemory / physiologyen_US
dc.subject.meshMental Recall / physiologyen_US
dc.subject.meshMiceen_US
dc.subject.meshNeurons / physiologyen_US
dc.subject.meshPhysical Stimulationen_US
dc.subject.meshTime Factorsen_US
dc.titleNeural population-level memory traces in the mouse hippocampus.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, N.I.H., Extramuralen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.identifier.pmcidPMC2788416en_US
dc.contributor.corporatenameBrain & Behavior Discovery Instituteen_US
dc.contributor.corporatenameDepartment of Neurologyen_US

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