Hdl Handle:
http://hdl.handle.net/10675.2/133
Title:
Sodium-coupled monocarboxylate transporters in normal tissues and in cancer.
Authors:
Ganapathy, Vadivel; Thangaraju, Muthusamy; Gopal, Elangovan; Martin, Pamela M; Itagaki, Shiro; Miyauchi, Seiji; Prasad, Puttur D
Abstract:
SLC5A8 and SLC5A12 are sodium-coupled monocarboxylate transporters (SMCTs), the former being a high-affinity type and the latter a low-affinity type. Both transport a variety of monocarboxylates in a Na(+)-coupled manner. They are expressed in the gastrointestinal tract, kidney, thyroid, brain, and retina. SLC5A8 is localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule. In the brain and retina, its expression is restricted to neurons and the retinal pigment epithelium. The physiologic functions of SLC5A8 include absorption of short-chain fatty acids in the colon and small intestine, reabsorption of lactate and pyruvate in the kidney, and cellular uptake of lactate and ketone bodies in neurons. It also transports the B-complex vitamin nicotinate. SLC5A12 is also localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule. In the brain and retina, its expression is restricted to astrocytes and M?�ller cells. SLC5A8 also functions as a tumor suppressor; its expression is silenced in tumors of colon, thyroid, stomach, kidney, and brain. The tumor-suppressive function is related to its ability to mediate concentrative uptake of butyrate, propionate, and pyruvate, all of which are inhibitors of histone deacetylases. SLC5A8 can also transport a variety of pharmacologically relevant monocarboxylates, including salicylates, benzoate, and gamma-hydroxybutyrate. Non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen, and fenoprofen, also interact with SLC5A8. These drugs are not transportable substrates for SLC5A8, but instead function as blockers of the transporter. Relatively less is known on the role of SLC5A12 in drug transport.
Citation:
AAPS J. 2008 Apr 2; 10(1):193-199
Issue Date:
30-Apr-2008
URI:
http://hdl.handle.net/10675.2/133
DOI:
10.1208/s12248-008-9022-y
PubMed ID:
18446519
PubMed Central ID:
PMC2751467
Type:
Comparative Study; Journal Article; Review
ISSN:
1550-7416
Appears in Collections:
Department of Biochemistry and Molecular Biology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorGanapathy, Vadivelen_US
dc.contributor.authorThangaraju, Muthusamyen_US
dc.contributor.authorGopal, Elangovanen_US
dc.contributor.authorMartin, Pamela Men_US
dc.contributor.authorItagaki, Shiroen_US
dc.contributor.authorMiyauchi, Seijien_US
dc.contributor.authorPrasad, Puttur Den_US
dc.date.accessioned2010-09-24T22:03:25Z-
dc.date.available2010-09-24T22:03:25Z-
dc.date.issued2008-04-30en_US
dc.identifier.citationAAPS J. 2008 Apr 2; 10(1):193-199en_US
dc.identifier.issn1550-7416en_US
dc.identifier.pmid18446519en_US
dc.identifier.doi10.1208/s12248-008-9022-yen_US
dc.identifier.urihttp://hdl.handle.net/10675.2/133-
dc.description.abstractSLC5A8 and SLC5A12 are sodium-coupled monocarboxylate transporters (SMCTs), the former being a high-affinity type and the latter a low-affinity type. Both transport a variety of monocarboxylates in a Na(+)-coupled manner. They are expressed in the gastrointestinal tract, kidney, thyroid, brain, and retina. SLC5A8 is localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule. In the brain and retina, its expression is restricted to neurons and the retinal pigment epithelium. The physiologic functions of SLC5A8 include absorption of short-chain fatty acids in the colon and small intestine, reabsorption of lactate and pyruvate in the kidney, and cellular uptake of lactate and ketone bodies in neurons. It also transports the B-complex vitamin nicotinate. SLC5A12 is also localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule. In the brain and retina, its expression is restricted to astrocytes and M?�ller cells. SLC5A8 also functions as a tumor suppressor; its expression is silenced in tumors of colon, thyroid, stomach, kidney, and brain. The tumor-suppressive function is related to its ability to mediate concentrative uptake of butyrate, propionate, and pyruvate, all of which are inhibitors of histone deacetylases. SLC5A8 can also transport a variety of pharmacologically relevant monocarboxylates, including salicylates, benzoate, and gamma-hydroxybutyrate. Non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen, and fenoprofen, also interact with SLC5A8. These drugs are not transportable substrates for SLC5A8, but instead function as blockers of the transporter. Relatively less is known on the role of SLC5A12 in drug transport.en_US
dc.rightsThe PMC Open Access Subset is a relatively small part of the total collection of articles in PMC. Articles in the PMC Open Access Subset are still protected by copyright, but are made available under a Creative Commons or similar license that generally allows more liberal redistribution and reuse than a traditional copyrighted work. Please refer to the license statement in each article for specific terms of use. The license terms are not identical for all articles in this subset.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshHumansen_US
dc.subject.meshMonocarboxylic Acid Transporters / metabolismen_US
dc.subject.meshNeoplasms / metabolismen_US
dc.subject.meshSodium / metabolismen_US
dc.subject.meshSodium Channels / metabolismen_US
dc.subject.meshSodium-Glucose Transport Proteins / metabolismen_US
dc.subject.meshTissue Distributionen_US
dc.titleSodium-coupled monocarboxylate transporters in normal tissues and in cancer.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
dc.identifier.pmcidPMC2751467en_US
dc.contributor.corporatenameDepartment of Biochemistry and Molecular Biologyen_US

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