Rab proteins in gastric parietal cells: evidence for the membrane recycling hypothesis.

Hdl Handle:
http://hdl.handle.net/10675.2/109
Title:
Rab proteins in gastric parietal cells: evidence for the membrane recycling hypothesis.
Authors:
Calhoun, Benjamin C ( 0000-0001-6505-5430 ) ; Goldenring, J R
Abstract:
The gastric parietal cell secretes large quantities of HCl into the lumen of the gastric gland in response to secretagogues such as histamine. In the membrane recycling hypothesis, this secretory activity requires the trafficking of the gastric H+/K(+)-ATPase to the cell surface from intracellular tubulovesicles. The Rab subclass of small GTP-binding proteins is thought to confer specificity to vesicle transport throughout the secretory pathway, and previous investigations established that Rab11 is highly expressed in gastric parietal cells. Recent discoveries in intra-Golgi transport and neuronal synaptic vesicle fusion have fortuitously converged on an evolutionarily conserved protein complex involved in vesicle docking and fusion. Recent results indicate that Rab11 is involved in the apical targeting of vesicles in parietal cells and other epithelial cells throughout the gastrointestinal tract. In support of the membrane recycling hypothesis, Rab co-segregates with H+/K(+)-ATPase in parietal cells. The presence of Rab11 on tubulovesicles supports a role for this Rab protein in recycling vesicle trafficking.
Citation:
Yale J Biol Med. 1996 Jan-Feb; 69(1):1-8
Issue Date:
8-Jul-1997
URI:
http://hdl.handle.net/10675.2/109
PubMed ID:
9041684
PubMed Central ID:
PMC2588980
Type:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review
ISSN:
0044-0086
Appears in Collections:
Department of Medicine Faculty: Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorCalhoun, Benjamin Cen_US
dc.contributor.authorGoldenring, J Ren_US
dc.date.accessioned2010-09-24T22:03:21Z-
dc.date.available2010-09-24T22:03:21Z-
dc.date.issued1997-07-08en_US
dc.identifier.citationYale J Biol Med. 1996 Jan-Feb; 69(1):1-8en_US
dc.identifier.issn0044-0086en_US
dc.identifier.pmid9041684en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/109-
dc.description.abstractThe gastric parietal cell secretes large quantities of HCl into the lumen of the gastric gland in response to secretagogues such as histamine. In the membrane recycling hypothesis, this secretory activity requires the trafficking of the gastric H+/K(+)-ATPase to the cell surface from intracellular tubulovesicles. The Rab subclass of small GTP-binding proteins is thought to confer specificity to vesicle transport throughout the secretory pathway, and previous investigations established that Rab11 is highly expressed in gastric parietal cells. Recent discoveries in intra-Golgi transport and neuronal synaptic vesicle fusion have fortuitously converged on an evolutionarily conserved protein complex involved in vesicle docking and fusion. Recent results indicate that Rab11 is involved in the apical targeting of vesicles in parietal cells and other epithelial cells throughout the gastrointestinal tract. In support of the membrane recycling hypothesis, Rab co-segregates with H+/K(+)-ATPase in parietal cells. The presence of Rab11 on tubulovesicles supports a role for this Rab protein in recycling vesicle trafficking.en_US
dc.rightsThe PMC Open Access Subset is a relatively small part of the total collection of articles in PMC. Articles in the PMC Open Access Subset are still protected by copyright, but are made available under a Creative Commons or similar license that generally allows more liberal redistribution and reuse than a traditional copyrighted work. Please refer to the license statement in each article for specific terms of use. The license terms are not identical for all articles in this subset.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Membrane / physiologyen_US
dc.subject.meshGTP-Binding Proteins / physiologyen_US
dc.subject.meshH(+)-K(+)-Exchanging ATPaseen_US
dc.subject.meshHumansen_US
dc.subject.meshParietal Cells, Gastric / physiologyen_US
dc.subject.meshrab GTP-Binding Proteinsen_US
dc.titleRab proteins in gastric parietal cells: evidence for the membrane recycling hypothesis.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.typeResearch Support, U.S. Gov't, P.H.S.en_US
dc.typeReviewen_US
dc.identifier.pmcidPMC2588980en_US
dc.contributor.corporatenameDepartment of Medicineen_US

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